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'''NSP9 PROTEIN FROM SARS-CORONAVIRUS.''' | '''NSP9 PROTEIN FROM SARS-CORONAVIRUS.''' | ||
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[[Category: Walsh, M.]] | [[Category: Walsh, M.]] | ||
[[Category: Walter, T.]] | [[Category: Walter, T.]] | ||
[[Category: | [[Category: Coronavirus]] | ||
[[Category: | [[Category: Replicase protein]] | ||
[[Category: | [[Category: Rna-binding]] | ||
[[Category: | [[Category: Sar]] | ||
[[Category: | [[Category: Viral protein]] | ||
[[Category: | [[Category: Virus]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:45:53 2008'' | |||
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Revision as of 11:45, 3 May 2008
NSP9 PROTEIN FROM SARS-CORONAVIRUS.
OverviewOverview
As part of a high-throughput structural analysis of SARS-coronavirus (SARS-CoV) proteins, we have solved the structure of the non-structural protein 9 (nsp9). This protein, encoded by ORF1a, has no designated function but is most likely involved with viral RNA synthesis. The protein comprises a single beta-barrel with a fold previously unseen in single domain proteins. The fold superficially resembles an OB-fold with a C-terminal extension and is related to both of the two subdomains of the SARS-CoV 3C-like protease (which belongs to the serine protease superfamily). nsp9 has, presumably, evolved from a protease. The crystal structure suggests that the protein is dimeric. This is confirmed by analytical ultracentrifugation and dynamic light scattering. We show that nsp9 binds RNA and interacts with nsp8, activities that may be essential for its function(s).
About this StructureAbout this Structure
1UW7 is a Single protein structure of sequence from Viruses. Full crystallographic information is available from OCA.
ReferenceReference
The nsp9 replicase protein of SARS-coronavirus, structure and functional insights., Sutton G, Fry E, Carter L, Sainsbury S, Walter T, Nettleship J, Berrow N, Owens R, Gilbert R, Davidson A, Siddell S, Poon LL, Diprose J, Alderton D, Walsh M, Grimes JM, Stuart DI, Structure. 2004 Feb;12(2):341-53. PMID:14962394 Page seeded by OCA on Sat May 3 11:45:53 2008