1uun: Difference between revisions

Revision as of 11:43, 3 May 2008

MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)

OverviewOverview

Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models.

About this StructureAbout this Structure

1UUN is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.

ReferenceReference

The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:14976314 Page seeded by OCA on Sat May 3 11:43:03 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1uun.jpg|left|200px]]
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 '''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)'''
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 [[Category: Niederweis, M.]]
 [[Category: Schulz, G E.]]
-[[Category: mycobacteria]]
+[[Category: Mycobacteria]]
-[[Category: porin]]
+[[Category: Porin]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:43:03 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:15:32 2008''