1uuj: Difference between revisions
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'''N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)''' | '''N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)''' | ||
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[[Category: Devedjiev, Y.]] | [[Category: Devedjiev, Y.]] | ||
[[Category: Kim, M H.]] | [[Category: Kim, M H.]] | ||
[[Category: | [[Category: Cell division]] | ||
[[Category: | [[Category: Cytoskeleton]] | ||
[[Category: | [[Category: Microtubule]] | ||
[[Category: | [[Category: Mitosis]] | ||
[[Category: | [[Category: Neurogenesis]] | ||
[[Category: | [[Category: Platelet-activating factor acetylhydrolase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:42:43 2008'' | |||
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Revision as of 11:42, 3 May 2008
N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)
OverviewOverview
Mutations in the Lis1 gene result in lissencephaly (smooth brain), a debilitating developmental syndrome caused by the impaired ability of postmitotic neurons to migrate to their correct destination in the cerebral cortex. Sequence similarities suggest that the LIS1 protein contains a C-terminal seven-blade beta-propeller domain, while the structure of the N-terminal fragment includes the LisH (Lis-homology) motif, a pattern found in over 100 eukaryotic proteins with a hitherto unknown function. We present the 1.75 A resolution crystal structure of the N-terminal domain of mouse LIS1, and we show that the LisH motif is a novel, thermodynamically very stable dimerization domain. The structure explains the molecular basis of a low severity form of lissencephaly.
About this StructureAbout this Structure
1UUJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications., Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS, Structure. 2004 Jun;12(6):987-98. PMID:15274919 Page seeded by OCA on Sat May 3 11:42:43 2008