1uru: Difference between revisions

Revision as of 11:36, 3 May 2008

AMPHIPHYSIN BAR DOMAIN FROM DROSOPHILA

OverviewOverview

The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved the structure of the Drosophila amphiphysin BAR domain. It is a crescent-shaped dimer that binds preferentially to highly curved negatively charged membranes. With its N-terminal amphipathic helix and BAR domain (N-BAR), amphiphysin can drive membrane curvature in vitro and in vivo. The structure is similar to that of arfaptin2, which we find also binds and tubulates membranes. From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module.

About this StructureAbout this Structure

1URU is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

ReferenceReference

BAR domains as sensors of membrane curvature: the amphiphysin BAR structure., Peter BJ, Kent HM, Mills IG, Vallis Y, Butler PJ, Evans PR, McMahon HT, Science. 2004 Jan 23;303(5657):495-9. Epub 2003 Nov 26. PMID:14645856 Page seeded by OCA on Sat May 3 11:36:11 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1uru.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1uru |SIZE=350|CAPTION= <scene name='initialview01'>1uru</scene>, resolution 2.60&Aring;
+The line below this paragraph, containing "STRUCTURE_1uru", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1uru|  PDB=1uru  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uru OCA], [http://www.ebi.ac.uk/pdbsum/1uru PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uru RCSB]</span>
-}}
 '''AMPHIPHYSIN BAR DOMAIN FROM DROSOPHILA'''
@@ Line 27: / Line 24: @@
 [[Category: Evans, P R.]]
 [[Category: Kent, H M.]]
-[[Category: coiled-coil]]
+[[Category: Coiled-coil]]
-[[Category: endocytosis]]
+[[Category: Endocytosis]]
-[[Category: membrane curvature]]
+[[Category: Membrane curvature]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:36:11 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:19 2008''