1u35: Difference between revisions

Revision as of 10:42, 3 May 2008

Crystal structure of the nucleosome core particle containing the histone domain of macroH2A

OverviewOverview

macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.

About this StructureAbout this Structure

1U35 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural characterization of the histone variant macroH2A., Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K, Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:16107708 Page seeded by OCA on Sat May 3 10:42:02 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1u35.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1u35 |SIZE=350|CAPTION= <scene name='initialview01'>1u35</scene>, resolution 3.0&Aring;
+The line below this paragraph, containing "STRUCTURE_1u35", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= H3FA, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+-->
-|DOMAIN=
+{{STRUCTURE_1u35|  PDB=1u35  |  SCENE=  }}
-|RELATEDENTRY=[[1aoi|1AOI]], [[1f66|1F66]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u35 OCA], [http://www.ebi.ac.uk/pdbsum/1u35 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u35 RCSB]</span>
-}}
 '''Crystal structure of the nucleosome core particle containing the histone domain of macroH2A'''
@@ Line 33: / Line 30: @@
 [[Category: Pehrson, J R.]]
 [[Category: Perche, P Y.]]
-[[Category: histone fold]]
+[[Category: Histone fold]]
-[[Category: histone variant]]
+[[Category: Histone variant]]
-[[Category: macroh2a]]
+[[Category: Macroh2a]]
-[[Category: ncp]]
+[[Category: Ncp]]
-[[Category: nucleosome]]
+[[Category: Nucleosome]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:42:02 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:04:47 2008''