8y0h: Difference between revisions

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-'''Unreleased structure'''
-The entry 8y0h is ON HOLD
+==Structure of CXCR3 in complex with VUF11418 (Receptor-ligand focused map)==
+<StructureSection load='8y0h' size='340' side='right'caption='[[8y0h]], [[Resolution|resolution]] 3.53&Aring;' scene=''>
-Authors: Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8y0h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y0H FirstGlance]. <br>
-Description: Structure of CXCR3 in complex with VUF11418 (Receptor-ligand focused map)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.53&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LW2:[(1~{R},5~{S})-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl-[[4-(2-iodanylphenyl)phenyl]methyl]-dimethyl-azanium'>A1LW2</scene></td></tr>
-[[Category: Shukla, A.K]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y0h OCA], [https://pdbe.org/8y0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y0h RCSB], [https://www.ebi.ac.uk/pdbsum/8y0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y0h ProSAT]</span></td></tr>
-[[Category: Saha, S]]
+</table>
-[[Category: Banerjee, R]]
+== Function ==
-[[Category: Sano, F.K]]
+[https://www.uniprot.org/uniprot/CXCR3_HUMAN CXCR3_HUMAN] Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling.<ref>PMID:12782716</ref> <ref>PMID:18174362</ref> <ref>PMID:24469069</ref>   Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.<ref>PMID:12782716</ref>   Mediates the activity of CXCL11.
-[[Category: Ganguly, M]]
+== References ==
-[[Category: Sharma, S]]
+<references/>
-[[Category: Nureki, O]]
+__TOC__
-[[Category: Shihoya, W]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Banerjee R]]
+[[Category: Ganguly M]]
+[[Category: Nureki O]]
+[[Category: Saha S]]
+[[Category: Sano FK]]
+[[Category: Sharma S]]
+[[Category: Shihoya W]]
+[[Category: Shukla AK]]