HIF1A: Difference between revisions
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== Disease == | == Disease == | ||
Hypoxia-inducible factors (HIFs) are essential in the progression of various diseases, including cancer and conditions such as peripheral arterial disease, pulmonary arterial hypertension, and sleep apnea. They also play a significant role in regulating insulin signaling and obesity. | |||
Under hypoxic conditions, HIFs are stabilized and activate the expression of genes related to cellular adaptation to oxygen deprivation. In the presence of oxygen, HIFs are degraded, but during hypoxia, they form active complexes and promote important cellular changes. | |||
Hypoxia is a common feature in solid tumors and their metastases, leading to the activation of HIFs, which influence gene expression in both tumor cells and immune cells in the tumor microenvironment. This affects tumor progression and treatment response. | |||
In particular, HIF-1α is crucial in the initiation of certain types of cancer, such as clear cell renal cell carcinoma (ccRCC), and is elevated in pre-neoplastic stages. | |||
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
Alves, Cinthia C, Eduardo A Donadi, and Silvana Giuliatti. 2021. “Structural Characterization of the Interaction of Hypoxia Inducible Factor-1 with Its Hypoxia Responsive Element at the −964G > a Variation Site of the HLA-G Promoter Region.” International Journal of Molecular Sciences 22 (23): 13046–46. https://doi.org/10.3390/ijms222313046. | |||
<references/> | <references/> | ||