9b4e: Difference between revisions

Latest revision as of 08:42, 4 September 2024

Structure of wild type human PSS1Structure of wild type human PSS1

Structural highlights

9b4e is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.7Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

PTSS1_HUMAN Lenz-Majewski hyperostotic dwarfism. The disease is caused by variants affecting the gene represented in this entry.

Function

PTSS1_HUMAN Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535).^[1] ^[2]

References

↑ Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O. Purification and characterization of human phosphatidylserine synthases 1 and 2. Biochem J. 2009 Mar 1;418(2):421-9. PMID:19014349 doi:10.1042/BJ20081597
↑ Sousa SB, Jenkins D, Chanudet E, Tasseva G, Ishida M, Anderson G, Docker J, Ryten M, Sa J, Saraiva JM, Barnicoat A, Scott R, Calder A, Wattanasirichaigoon D, Chrzanowska K, Simandlová M, Van Maldergem L, Stanier P, Beales PL, Vance JE, Moore GE. Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome. Nat Genet. 2014 Jan;46(1):70-6. PMID:24241535 doi:10.1038/ng.2829

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OCA

[1] Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O. Purification and characterization of human phosphatidylserine synthases 1 and 2. Biochem J. 2009 Mar 1;418(2):421-9. PMID:19014349 doi:10.1042/BJ20081597

[2] Sousa SB, Jenkins D, Chanudet E, Tasseva G, Ishida M, Anderson G, Docker J, Ryten M, Sa J, Saraiva JM, Barnicoat A, Scott R, Calder A, Wattanasirichaigoon D, Chrzanowska K, Simandlová M, Van Maldergem L, Stanier P, Beales PL, Vance JE, Moore GE. Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome. Nat Genet. 2014 Jan;46(1):70-6. PMID:24241535 doi:10.1038/ng.2829

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9b4e is ON HOLD
+==Structure of wild type human PSS1==
+<StructureSection load='9b4e' size='340' side='right'caption='[[9b4e]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9b4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9B4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9B4E FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9b4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9b4e OCA], [https://pdbe.org/9b4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9b4e RCSB], [https://www.ebi.ac.uk/pdbsum/9b4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9b4e ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PTSS1_HUMAN PTSS1_HUMAN] Lenz-Majewski hyperostotic dwarfism. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/PTSS1_HUMAN PTSS1_HUMAN] Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:19014349, PubMed:24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:19014349, PubMed:24241535).<ref>PMID:19014349</ref> <ref>PMID:24241535</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li X]]
+[[Category: Long T]]

9b4e: Difference between revisions

Latest revision as of 08:42, 4 September 2024

Structure of wild type human PSS1Structure of wild type human PSS1

Structural highlights

Disease

Function

References

Contents

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9b4e: Difference between revisions

Latest revision as of 08:42, 4 September 2024

Structure of wild type human PSS1Structure of wild type human PSS1

Structural highlights

Disease

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

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