8rg0: Difference between revisions
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==Structure of human eIF3 core from closed 48S translation initiation complex== | |||
<StructureSection load='8rg0' size='340' side='right'caption='[[8rg0]], [[Resolution|resolution]] 3.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8rg0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RG0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rg0 OCA], [https://pdbe.org/8rg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rg0 RCSB], [https://www.ebi.ac.uk/pdbsum/8rg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rg0 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/EIF3K_HUMAN EIF3K_HUMAN] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Fischer N]] | |||
[[Category: Liedtke D]] | |||
[[Category: Peng BZ]] | |||
[[Category: Petrychenko V]] | |||
[[Category: Rodnina MV]] | |||
[[Category: Yi S-H]] | |||