8tle: Difference between revisions

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'''Unreleased structure'''


The entry 8tle is ON HOLD  until Paper Publication
==CDCA7 (Mouse) Binds Non-B-form 36-mer DNA oligo (sg C2-Form 1)==
 
<StructureSection load='8tle' size='340' side='right'caption='[[8tle]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8tle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TLE FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tle OCA], [https://pdbe.org/8tle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tle RCSB], [https://www.ebi.ac.uk/pdbsum/8tle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tle ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDCA7_MOUSE CDCA7_MOUSE] Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity).<ref>PMID:16580749</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Cheng X]]
[[Category: Horton JR]]
[[Category: Ren R]]

Latest revision as of 16:06, 21 August 2024

CDCA7 (Mouse) Binds Non-B-form 36-mer DNA oligo (sg C2-Form 1)CDCA7 (Mouse) Binds Non-B-form 36-mer DNA oligo (sg C2-Form 1)

Structural highlights

8tle is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.08Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CDCA7_MOUSE Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity).[1]

References

  1. ↑ Goto Y, Hayashi R, Muramatsu T, Ogawa H, Eguchi I, Oshida Y, Ohtani K, Yoshida K. JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. Biochim Biophys Acta. 2006 Jan-Feb;1759(1-2):60-8. PMID:16580749 doi:10.1016/j.bbaexp.2006.02.004

8tle, resolution 2.08Å

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OCA
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