Salbutamol: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Ann Taylor

@@ Line 4: / Line 4: @@
 The <scene name='96/968805/Overall/1'>β2 adrenergic receptor</scene> is found in smooth muscles throughout the body, especially in the lungs.  It normally binds adrenaline, resulting in dialation of the bronchioles, which leads to increased oxygen intake. Salbutamol is an agonist, meaning it binds in the same place as adrenaline and stimulates the same response.
-The β2 adrenergic receptor has seven <scene name='96/968805/Hydrophobic_hydrophilic/1'> mostly hydrophobic </scene> (shown in grey; hydrophilic residues are shown in pink) alpha helices that cross the cell membrane.  When shown in a <scene name='96/968805/N_to_c_rainbow/1'>N to C rainbow</scene>, where the N terminus is shown in blue, the C terminus in red, and the intervening segments following the colors of the rainbow, the seven long helices that form a diagonal bundle, with shorter helices forming "caps" on either end can be seen more clearly.
+The β2 adrenergic receptor has seven <scene name='96/968805/Hydrophobic_hydrophilic/2'> mostly hydrophobic </scene> (shown in grey; hydrophilic residues are shown in pink) alpha helices that cross the cell membrane.  When shown in a <scene name='96/968805/N_to_c_rainbow/1'>N to C rainbow</scene>, where the N terminus is shown in blue, the C terminus in red, and the intervening segments following the colors of the rainbow, the seven long helices that form a diagonal bundle, with shorter helices forming "caps" on either end can be seen more clearly.
 The <scene name='96/968805/Binding_site/1'>Salbutamol binding site</scene> shows many intermolecular interactions between the protein and the drug. The phenyl ring of the salbutamol is sandwiched by <scene name='96/968805/Hydrophobic_pocket/1'>hydrophobic residues</scene>, while the N and O in salbutamol form <scene name='96/968805/H_bonds/1'>hydrogen bonds</scene> with nearby asparagine (Asn) and aspartate (Asp) residues.