|
|
| Line 10: |
Line 10: |
| == Function == | | == Function == |
| [https://www.uniprot.org/uniprot/TKTC_MAIZE TKTC_MAIZE] | | [https://www.uniprot.org/uniprot/TKTC_MAIZE TKTC_MAIZE] |
| <div style="background-color:#fffaf0;">
| |
| == Publication Abstract from PubMed ==
| |
| We report the design, synthesis and biological evaluation of simplified analogues of the herbicidal natural product (+)-cornexistin. Guided by an X-Ray co-crystal structure of cornexistin bound to the transketolase enzyme from Zea mays, we attempted to identify the key interactions that are necessary for cornexistin to maintain its herbicidal profile. This resulted in the preparation of three novel analogues investigating the importance of substituents that are located on the nine-membered ring of cornexistin. One analogue maintained a good level of biological activity and could provide researchers insights in how to further optimize the structure of cornexistin for commercialization in the future.
| |
|
| |
|
| Investigations into Simplified Analogues of the Herbicidal Natural Product (+)-Cornexistin.,Steinborn C, Tancredi A, Habiger C, Diederich C, Kramer J, Reingruber A, Laber B, Freigang J, Lange G, Schmutzler D, Machettira A, Besong G, Magauer T, Barber DM Chemistry. 2023 Feb 20:e202300199. doi: 10.1002/chem.202300199. PMID:36807428<ref>PMID:36807428</ref>
| | ==See Also== |
| | | *[[Transketolase 3D structures|Transketolase 3D structures]] |
| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| |
| </div>
| |
| <div class="pdbe-citations 8ci0" style="background-color:#fffaf0;"></div>
| |
| == References == | |
| <references/>
| |
| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |