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==Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)== | |||
<StructureSection load='8fxw' size='340' side='right'caption='[[8fxw]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8fxw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpox_virus_(Brighton_Red) Cowpox virus (Brighton Red)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FXW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fxw OCA], [https://pdbe.org/8fxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fxw RCSB], [https://www.ebi.ac.uk/pdbsum/8fxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fxw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q8QN22_CWPXB Q8QN22_CWPXB] Plays a role in immune evasion. When secreted, inhibits T-cell activation by preventing the binding of host CD80 and CD86 to soluble CTLA4 and CD28. In the infected cell, may inhibits host NF kappa B activation.[ARBA:ARBA00045309] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Adams LJ]] | |||
[[Category: Elliott JI]] | |||
[[Category: Fremont DH]] | |||
[[Category: Nelson CA]] | |||
Latest revision as of 09:20, 5 February 2025
Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring)
Structural highlights
FunctionQ8QN22_CWPXB Plays a role in immune evasion. When secreted, inhibits T-cell activation by preventing the binding of host CD80 and CD86 to soluble CTLA4 and CD28. In the infected cell, may inhibits host NF kappa B activation.[ARBA:ARBA00045309] |
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