7x66: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 7: Line 7:
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x66 OCA], [https://pdbe.org/7x66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x66 RCSB], [https://www.ebi.ac.uk/pdbsum/7x66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x66 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x66 OCA], [https://pdbe.org/7x66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x66 RCSB], [https://www.ebi.ac.uk/pdbsum/7x66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x66 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
 
[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref>  mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
==See Also==
== References ==
*[[Spike protein 3D structures|Spike protein 3D structures]]
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 12:20, 17 October 2024

SARS-CoV-2-Omicron-RBD and BD-236-GWP/P-VK antibody complexSARS-CoV-2-Omicron-RBD and BD-236-GWP/P-VK antibody complex

Structural highlights

7x66 is a 3 chain structure with sequence from Homo sapiens and Severe acute respiratory syndrome coronavirus 2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

7x66, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=7x66&oldid=4235078"