7b7c: Difference between revisions

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<StructureSection load='7b7c' size='340' side='right'caption='[[7b7c]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='7b7c' size='340' side='right'caption='[[7b7c]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7b7c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_laumondii Photorhabdus laumondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B7C FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B7C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b7c OCA], [https://pdbe.org/7b7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b7c RCSB], [https://www.ebi.ac.uk/pdbsum/7b7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b7c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b7c OCA], [https://pdbe.org/7b7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b7c RCSB], [https://www.ebi.ac.uk/pdbsum/7b7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b7c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q7N8J0_PHOLL Q7N8J0_PHOLL]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Carbohydrate-binding proteins from pathogenic bacteria and fungi have been shown to be implicated in various pathological processes, where they interact with glycans present on the surface of the host cells. These interactions are part of the initial processes of infection of the host and are very important to study at the atomic level. Here, we report the room temperature neutron structures of PLL lectin from Photorhabdus laumondii in its apo form and in complex with deuterated L-fucose, which is, to our knowledge, the first neutron structure of a carbohydrate-binding protein in complex with a fully deuterated carbohydrate ligand. A detailed structural analysis of the lectin-carbohydrate interactions provides information on the hydrogen bond network, the role of water molecules, and the extent of the CH-pi stacking interactions between fucose and the aromatic amino acids in the binding site.
Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions.,Gajdos L, Blakeley MP, Kumar A, Wimmerova M, Haertlein M, Forsyth VT, Imberty A, Devos JM Structure. 2021 Mar 24. pii: S0969-2126(21)00076-9. doi:, 10.1016/j.str.2021.03.003. PMID:33765407<ref>PMID:33765407</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7b7c" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Photorhabdus laumondii]]
[[Category: Blakeley MP]]
[[Category: Blakeley MP]]
[[Category: Devos JM]]
[[Category: Devos JM]]

Latest revision as of 13:52, 23 October 2024

Room temperature X-ray structure of perdeuterated PLL lectin in complex with L-fucoseRoom temperature X-ray structure of perdeuterated PLL lectin in complex with L-fucose

Structural highlights

Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.55Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

7b7c, resolution 1.55Å

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