6ud0: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ud0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UD0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ud0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UD0 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ud0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ud0 OCA], [https://pdbe.org/6ud0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ud0 RCSB], [https://www.ebi.ac.uk/pdbsum/6ud0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ud0 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ud0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ud0 OCA], [https://pdbe.org/6ud0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ud0 RCSB], [https://www.ebi.ac.uk/pdbsum/6ud0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ud0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
 
[https://www.uniprot.org/uniprot/UBB_HUMAN UBB_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
==See Also==
== References ==
*[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]]
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Latest revision as of 11:23, 17 October 2024

Solution-state NMR structural ensemble of human Tsg101 UEV in complex with K63-linked diubiquitinSolution-state NMR structural ensemble of human Tsg101 UEV in complex with K63-linked diubiquitin

Structural highlights

6ud0 is a 3 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

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