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==Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class== | ==Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class== | ||
<StructureSection load='6rsd' size='340' side='right'caption='[[6rsd]]' scene=''> | <StructureSection load='6rsd' size='340' side='right'caption='[[6rsd]], [[Resolution|resolution]] 1.76Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RSD OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RSD FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KH8:1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide'>KH8</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rsd OCA], [https://pdbe.org/6rsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rsd RCSB], [https://www.ebi.ac.uk/pdbsum/6rsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rsd ProSAT]</span></td></tr> | |||
</table> | </table> | ||
==See Also== | |||
*[[Janus kinase 3D structures|Janus kinase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Latest revision as of 11:18, 17 October 2024
Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole classStructure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
Structural highlights
See Also |
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