Cyclin-dependent kinase 3D structures: Difference between revisions
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*CDK2 | *CDK2 | ||
**[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]], [[5ano]] – hCDK2<br /> | **[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]], [[5ano]], [[8ru8]] – hCDK2<br /> | ||
**[[6yl6]] - hCDK2 (mutant)<br /> | **[[6yl6]] - hCDK2 (mutant)<br /> | ||
**[[1b39]] - hCDK2 T160P<br /> | **[[1b39]] - hCDK2 T160P<br /> | ||
**[[ | **[[1aq1]], [[1ckp]], [[1di8]], [[1dm2]], [[1e1v]], [[1e1x]], [[1fvt]], [[1fvv]], [[1g5s]], [[1gih]], [[1gii]], [[1gij]], [[1gz8]], [[1h00]], [[1h01]], [[1h07]], [[1h08]], [[1h0v]], [[1h0w]], [[1jsv]], [[1jvp]], [[1ke5]], [[1ke6]], [[1ke7]], [[1ke8]], [[1ke9]], [[1oiq]], [[1oir]], [[1oit]], [[1p2a]], [[1pf8]], [[1pxi]], [[1pxj]], [[1pxk]], [[1pxl]], [[1pxn]], [[1pxo]], [[1pxp]], [[1pye]], [[1r78]], [[1urw]], [[1v1k]], [[1vyw]], [[1vyz]], [[1w0x]], [[1w8c]], [[1wcc]], [[1y8y]], [[1y91]], [[2a0c]], [[2a4l]], [[2b52]], [[2b53]], [[2b54]], [[2b55]], [[2bhe]], [[2bhh]], [[2bpm]], [[2btr]], [[2bts]], [[2c68]], [[2c69]], [[2c6i]], [[2c6k]], [[2c6l]], [[2c6m]], [[2c6o]], [[2c6t]], [[2clx]], [[2duv]], [[2exm]], [[2fvd]], [[2j9m]], [[2r3f]], [[2r3g]], [[2r3h]], [[2r3i]], [[2r3j]], [[2r3k]], [[2r3l]], [[2r3m]], [[2r3n]], [[2r3o]], [[2r3p]], [[2r3q]], [[2r3r]], [[2r64]], [[2v0d]], [[2vta]], [[2vth]], [[2vti]], [[2vtj]], [[2vtl]], [[2vtm]], [[2vtn]], [[2vto]], [[2vtp]], [[2vtq]], [[2vtr]], [[2vts]], [[2vtt]], [[2vu3]], [[2vv9]], [[2w05]], [[2w06]], [[2w17]], [[2w1h]], [[2xmy]], [[2xnb]], [[3ezr]], [[3ezv]], [[3fz1]], [[3ig7]], [[3igg]], [[3le6]], [[3lfn]], [[3lfq]], [[3lfs]], [[3ns9]], [[3pj8]], [[3pxf]], [[3pxq]], [[3pxr]], [[3pxy]], [[3pxz]], [[3py0]], [[3py1]], [[3ql8]], [[3qqf]], [[3qqg]], [[3qqh]], [[3qqj]], [[3qqk]], [[3qrt]], [[3qru]], [[3qtq]], [[3qtr]], [[3qts]], [[3qtu]], [[3qtw]], [[3qtx]], [[3qtz]], [[3qu0]], [[3qwj]], [[3qwk]], [[3qx2]], [[3qx4]], [[3qxo]], [[3qxp]], [[3qzf]], [[3qzg]], [[3qzh]], [[3qzi]], [[3r1q]], [[3r1s]], [[3r1y]], [[3r28]], [[3r6x]], [[3r71]], [[3r73]], [[3r7e]], [[3r7i]], [[3r7u]], [[3r7v]], [[3r7y]], [[3r83]], [[3r8l]], [[3r8m]], [[3r8p]], [[3r8u]], [[3r8v]], [[3r8z]], [[3r9d]], [[3r9h]], [[3r9n]], [[3r9o]], [[3rah]], [[3rai]], [[3rak]], [[3ral]], [[3rjc]], [[3rk5]], [[3rk7]], [[3rk9]], [[3rkb]], [[3rm6]], [[3rm7]], [[3rmf]], [[3rni]], [[3roy]], [[3rpo]], [[3rpr]], [[3rpv]], [[3rpy]], [[3rzb]], [[3s00]], [[3s0o]], [[3s1h]], [[3s2p]], [[3sqq]], [[3sw4]], [[3sw7]], [[3ti1]], [[3tiy]], [[3tiz]], [[3uli]], [[3unj]], [[3unk]], [[3wbl]], [[4acm]], [[4bgh]], [[4ek4]], [[4ek5]], [[4ek6]], [[4ek8]], [[4ez3]], [[4ez7]], [[4fkg]], [[4fki]], [[4fkj]], [[4fkl]], [[4fko]], [[4fkp]], [[4fkq]], [[4fkr]], [[4fks]], [[4fkt]], [[4fku]], [[4fkv]], [[4fkw]], [[4gcj]], [[4kd1]], [[4lyn]], [[4nj3]], [[4bzd]], [[4rj3]], [[3qql]], [[5osj]], [[5oo0]], [[5mhq]], [[5k4j]], [[5jq8]], [[5jq5]], [[5iey]], [[5iex]], [[5fp6]], [[5fp5]], [[5d1j]], [[5ank]], [[5anj]], [[5ani]], [[5ang]], [[5ane]], [[5and]], [[5a14]], [[4d1z]], [[4d1x]], [[6guk]], [[6guh]], [[6inl]], [[6jgm]], [[6oqi]], [[7m2f]], [[7ra2]], [[7ra5]], [[7rwe]], [[7rwf]], [[7rxo]],[[7s4t]], [[7s7a]], [[7s84]], [[7s85]], [[7s9x]], [[7sa0]], [[7ug1]], [[7vdu]], [[7zpx]], [[8cur]], [[8erd]], [[8ern]], [[8oy2]], [[8uv0]] – hCDK2 + inhibitor<br /> | ||
**[[2ds1]], [[5osm]], [[5oo3]], [[5oo1]], [[6yl1]], [[6ylk]] – hCDK2 (mutant) + inhibitor<br /> | |||
**[[6q3b]], [[6q3c]], [[6q3f]], [[6q48]], [[6q49]], [[6q4a]], [[6q4b]], [[6q4c]], [[6q4d]], [[6q4e]], [[6q4f]], [[6q4g]], [[6q4h]], [[6q4i]], [[6q4j]], [[6q4k]] – hCDK2 + fraglite<br /> | **[[6q3b]], [[6q3c]], [[6q3f]], [[6q48]], [[6q49]], [[6q4a]], [[6q4b]], [[6q4c]], [[6q4d]], [[6q4e]], [[6q4f]], [[6q4g]], [[6q4h]], [[6q4i]], [[6q4j]], [[6q4k]] – hCDK2 + fraglite<br /> | ||
**[[5iev]] – hCDK2 + drug<br /> | **[[5iev]] – hCDK2 + drug<br /> | ||
**[[1fq1]] - hCDK2 + cyclin-dependent kinase inhibitor 3<br /> | **[[8fow]], [[8fp0]] – hCDK2 + drug + inhibitor<br /> | ||
**[[8fp5]] – hCDK2 + ATP<br /> | |||
**[[1fq1]] - hCDK2 +cyclin-dependent kinase inhibitor 3<br /> | |||
**[[5uq3]] - hCDK2 + speedy protein A + cyclin-dependent kinase inhibitor 3<br /> | **[[5uq3]] - hCDK2 + speedy protein A + cyclin-dependent kinase inhibitor 3<br /> | ||
**[[5uq2]], [[5uq1]] - hCDK2 + speedy protein A <br /> | **[[5uq2]], [[5uq1]] - hCDK2 + speedy protein A <br /> | ||
**[[7e34]] - hCDK2 + speedy protein A + SUN1<br /> | **[[7e34]] - hCDK2 + speedy protein A + SUN1<br /> | ||
**[[1buh]] – hCDK2 + protein CKSHS1<br /> | **[[1buh]] – hCDK2+ protein CKSHS1<br /> | ||
**[[4erw]], [[7nvq]] – hCDK2 + staurosporine<br /> | **[[4erw]], [[7nvq]] – hCDK2 + staurosporine<br /> | ||
**[[7uxi]], [[7uxk]], [[8umy]] – hCDK2+ polypeptide<br /> | |||
*CDK2+cyclin | *CDK2+cyclin | ||
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**[[2jgz]] - hCDK2 T160P + cyclin B1<br /> | **[[2jgz]] - hCDK2 T160P + cyclin B1<br /> | ||
**[[1w98]], [[5l2w]], [[7kjs]] - hCDK2 + cyclin E1<br /> | **[[1w98]], [[5l2w]], [[7kjs]] - hCDK2 + cyclin E1<br /> | ||
**[[ | **[[8h6p]], [[8h6t]], [[8vq3]], [[8vq4]] - hCDK2 + cyclin E1 + inhibitor<br /> | ||
**[[ | **[[1gy3]], [[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[2cch]], [[2v22]], [[2wev]], [[2wfy]], [[2whb]], [[2wma]], [[2wmb]], [[2x1n]], [[3qhr]], [[3qhw]], [[6p3w]] - hCDK2 + cyclin A2+peptide ligand<br /> | ||
**[[1fin]], [[1p5e]], [[1pkd]], [[1ykr]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[2c4g]], [[2i40]], [[2uue]], [[2uzb]], [[2uzd]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2wih]], [[2wip]], [[2wpa]], [[2wxv]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfm]], [[4cfn]], [[4cfu]], [[4cfv]], [[4cfw]], [[4cfx]], [[4fx3]], [[6gva]], [[6guf]], [[6gue]], [[6guc]], [[6rij]], [[7ack]], [[7b7s]], [[7mkx]], [[7qhl]], [[8b54]] – hCDK2 + cyclin A2 + inhibitor<br /> | |||
**[[6ath]] - hCDK2 T160P+ cyclin A2 + CDK inhibitor 1B<br /> | **[[6ath]] - hCDK2 T160P+ cyclin A2 + CDK inhibitor 1B<br /> | ||
**[[ | **[[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[1jst]], [[1ogu]], [[1oi9]], [[1oiu]], [[1oiy]], [[2cjm]], [[2g9x]], [[2iw6]], [[2iw8]], [[2iw9]], [[3bht]], [[3bhu]], [[3bhv]], [[3ddp]], [[3ddq]], [[3dog]], [[3tnw]], [[4bck]], [[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]], [[5cyi]], [[5nev]], [[5lmk]] - hCDK2 T160P+ cyclin A2 + inhibitor<br /> | ||
**[[2cci]], [[1qmz]] - hCDK2 T160P + cyclin A2 + peptide ligand<br /> | **[[8bzo]] - hCDK2 T160P + hCYCA2 + p27 – Cryo EM | ||
**[[2cci]], [[1qmz]] - hCDK2 T160P + cyclin A2+peptide ligand<br /> | |||
**[[1e9h]] - hCDK2 T160P + cyclin A3 + inhibitor<br /> | **[[1e9h]] - hCDK2 T160P + cyclin A3 + inhibitor<br /> | ||
**[[1jsu]] - hCDK2 T160P + cyclin A2+ protein P27<br /> | **[[1jsu]] - hCDK2 T160P + cyclin A2+ protein P27<br /> | ||
**[[4i3z]], [[4ii5]] - hCDK2 T160P + cyclin A2+ ADP<br /> | **[[4i3z]], [[4ii5]] - hCDK2 T160P + cyclin A2+ ADP<br /> | ||
**[[1f5q]] - hCDK2 + | **[[1f5q]] - hCDK2 + g herpesvirus cyclin <br /> | ||
**[[7b5r]] - hCDK2 + cyclin A + cullin1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 – cryo EM<br /> | **[[7b5r]] - hCDK2 + cyclin A + cullin1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 – cryo EM<br /> | ||
**[[7b5m]] - hCDK2 + cyclin A + cullin1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 + ARIH1 + Ub – cryo EM<br /> | **[[7b5m]] - hCDK2 + cyclin A + cullin1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 + ARIH1 + Ub – cryo EM<br /> | ||
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**[[1fpz]] – hCDK3 (mutant) | **[[1fpz]] – hCDK3 (mutant) | ||
**[[7xqk]] – hCDK3 + hCYCE1 <br /> | |||
**[[8h4r]] – hCDK3 + hCYCE1 + drug<br /> | |||
*CDK4 | *CDK4 | ||
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**[[4au8]] – hCDK5 + inhibitor<br /> | **[[4au8]] – hCDK5 + inhibitor<br /> | ||
**[[3o0g]] - hCDK5 + ATP analog + CDK5 activator<br /> | **[[3o0g]] - hCDK5 + ATP analog + CDK5 activator<br /> | ||
**[[7vdp]], [[7vdq]], [[7vdr]], [[7vds]] – hCDK5 + p25 + inhibitor<br /> | |||
*CDK6 | *CDK6 | ||
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**[[1ua2]] – hCDK7<br /> | **[[1ua2]] – hCDK7<br /> | ||
**[[8r99]], [[8r9a]], [[8r9b]], [[8r9o]], [[8r9s]], [[8r9u]] – hCDK7 + AMPPNP<br /> | |||
**[[8p4z]] – hCDK7 + inhibitor<br /> | |||
**[[6o9l]] – hCDK7 in transcription preinitiation complex – Cryo EM<br /> | **[[6o9l]] – hCDK7 in transcription preinitiation complex – Cryo EM<br /> | ||
**[[6xbz]], [[7b5o]], [[7b5q]] – hCDK7 + cyclin H + MAT1 – Cryo EM<br /> | **[[8pyr]] – hCDK7 + cyclin H + MAT1 <br /> | ||
**[[6xbz]], [[7b5o]], [[7b5q]], [[8orm]], [[8p6w]], [[8p6x]], [[8p73]], [[8p74]], [[8p75]], [[8p79]] – hCDK7 + cyclin H + MAT1 – Cryo EM<br /> | |||
**[[8p7l]] – hCDK7 + MAT1 + inhibitor – Cryo EM<br /> | |||
**[[8p6v]], [[8p6z]], [[8p70]], [[8p71]], [[8p72]], [[8p76]], [[8p77]], [[8plz]], [[8s0t]] – hCDK7 + cyclin H + MAT1 + inhibitor – Cryo EM<br /> | |||
**[[8p78]] – hCDK7 + cyclin H + MAT1 + drug – Cryo EM<br /> | |||
**[[8p6y]] – hCDK7 + hCYCH + MAT1 + ATPgS – Cryo EM<br /> | |||
**[[7nvr]] – hCDK7 + hCYCH in DNA polymerase complex – Cryo EM<br /> | |||
*CDK8 | *CDK8 | ||
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**[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4c4l]], [[5bnj]], [[5cei]], [[5fgk]], [[5hbe]], [[5hbh]], [[5hbj]], [[5hnb]], [[5hvy]], [[5i5z]], [[5icp]], [[5idn]], [[5idp]], [[5xs2]], [[5xqx]], [[4f7s]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]], [[6y0a]] – hCDK8 + cyclin C + inhibitor<br /> | **[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4c4l]], [[5bnj]], [[5cei]], [[5fgk]], [[5hbe]], [[5hbh]], [[5hbj]], [[5hnb]], [[5hvy]], [[5i5z]], [[5icp]], [[5idn]], [[5idp]], [[5xs2]], [[5xqx]], [[4f7s]], [[6qtg]], [[6qtj]], [[6r3s]], [[6t41]], [[6y0a]] – hCDK8 + cyclin C + inhibitor<br /> | ||
**[[6tpa]] – hCDK8 + cyclin C + drug<br /> | **[[6tpa]] – hCDK8 + cyclin C + drug<br /> | ||
**[[8tqc]] – hCDK8 + hCYCC + mediator of RNA polymerase transcription subunit 12,13 – Cryo EM<br /> | |||
**[[8tqw]] – hCDK8 + hCYCC + mediator of RNA polymerase transcription complex– Cryo EM<br /> | |||
*CDK9 | *CDK9 | ||
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**[[3blh]], [[4ec8]], [[4ec9]] – hCDK9-P + cyclin T1 (mutant)<br /> | **[[3blh]], [[4ec8]], [[4ec9]] – hCDK9-P + cyclin T1 (mutant)<br /> | ||
**[[3blq]] – hCDK9-P + cyclin T1 (mutant) + ATP<br /> | **[[3blq]] – hCDK9-P + cyclin T1 (mutant) + ATP<br /> | ||
**[[3lq5]], [[3my1]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]], [[6gzh]], [[6z45]], [[7nwk]] – hCDK9-P + cyclin T1 (mutant) + inhibitor<br /> | **[[3lq5]], [[3my1]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]], [[6gzh]], [[6w9e]], [[6z45]], [[7nwk]], [[8k5r]] – hCDK9-P + cyclin T1 (mutant) + inhibitor<br /> | ||
**[[3blr]] – hCDK9-P + cyclin T1 + flavopiridol<br /> | **[[3blr]] – hCDK9-P + cyclin T1 + flavopiridol<br /> | ||
**[[3mi9]], [[3mia]] – hCDK9-P + cyclin T1 + HIV-1 TAT<br /> | **[[3mi9]], [[3mia]] – hCDK9-P + cyclin T1 + HIV-1 TAT<br /> | ||
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**[[4nst]] – hCDK12-P + cyclin K + AlF3<br /> | **[[4nst]] – hCDK12-P + cyclin K + AlF3<br /> | ||
**[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br /> | **[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br /> | ||
**[[6b3e]], [[5acb]], [[6b3p]], [[6ckx]], [[7nxk]] – hCDK12-P + cyclin K + inhibitor<br /> | **[[6b3e]], [[5acb]], [[6b3p]], [[6ckx]], [[7nxk]], [[8p81]] – hCDK12-P + cyclin K + inhibitor<br /> | ||
**[[6td3]] - hCDK12-P + cyclin K + DDB1<br /> | **[[6td3]], [[8bu1]], [[8bu2]], [[8bu3]], [[8bu4]], [[8bu5]], [[8bu6]], [[8bu7]], [[8bu9]], [[8bua]], [[8bub]], [[8buc]], [[8bud]], [[8bue]], [[8buf]], [[8bug]], [[8buh]], [[8bui]], [[8buj]], [[8buk]], [[8bul]], [[8bum]], [[8bun]], [[8buo]], [[8bup]], [[8buq]], [[8bur]], [[8bus]], [[8but]], [[9fmr]] - hCDK12-P + cyclin K + DDB1 + inhibitor<br /> | ||
*CDK13 | *CDK13 | ||