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Caspase 3D structures: Difference between revisions

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**[[1sc3]] - hCASP (mutant) + malonate<br />
**[[1sc3]] - hCASP (mutant) + malonate<br />
**[[6bz9]] - hCASP + polypeptide inhibitor<br />
**[[6bz9]] - hCASP + polypeptide inhibitor<br />
**[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]], [[5mtk]], [[5mmv]], [[6f6r]] - hCASP (mutant) + polypeptide inhibitor<br />
**[[1ibc]], [[3d6f]], [[3d6h]], [[3d6m]], [[5mmv]], [[5mtk]], [[6f6r]] - hCASP (mutant) + polypeptide inhibitor<br />
**[[2hbq]], [[1bmq]], [[3ns7]] - hCASP + inhibitor<br />
**[[1bmq]], [[2hbq]], [[3ns7]] - hCASP + inhibitor<br />
**[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br />
**[[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]], [[2fqq]], [[2h48]], [[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]] - hCASP (mutant) + inhibitor<br />
**[[1ice]] – hCASP + tetrapeptide aldehyde<br />
**[[1ice]] – hCASP + tetrapeptide aldehyde<br />
**[[6vie]] – hCASP + gasdermin<br />
**[[6vie]] – hCASP + gasdermin<br />
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**[[2xyg]], [[2xyh]], [[2xyp]], [[4jje]] – hCASP subunits P12, P17 + inhibitor<br />
**[[2xyg]], [[2xyh]], [[2xyp]], [[4jje]] – hCASP subunits P12, P17 + inhibitor<br />
**[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br />
**[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br />
**[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]], [[4pry]] – hCASP + polypeptide inhibitor<br />
**[[1cp3]], [[1pau]], [[2cdr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2h65]], [[3edq]], [[3edr]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3pcx]], [[3pd0]], [[3pd1]], [[4pry]] – hCASP + polypeptide inhibitor<br />
**[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]], [[4ps0]], [[4ps1]], [[6ckz]], [[7rn7]], [[7rn8]], [[7rn9]], [[7rna]], [[7rnb]], [[7rnc]], [[7rnd]], [[7rne]], [[7rnf]], [[7rng]], [[7seo]], [[7uso]], [[7usp]], [[7usq]]  – hCASP subunits P12, P17 + polypeptide inhibitor<br />
**[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]], [[4ps0]], [[4ps1]], [[6ckz]], [[7rn7]], [[7rn8]], [[7rn9]], [[7rna]], [[7rnb]], [[7rnc]], [[7rnd]], [[7rne]], [[7rnf]], [[7rng]], [[7seo]], [[7uso]], [[7usp]], [[7usq]]  – hCASP subunits P12, P17 + polypeptide inhibitor<br />
**[[2dko]], [[2cjx]], [[2cjy]], [[4qtx]], [[4qty]], [[4qu0]], [[4qu5]], [[4qu8]], [[4qu9]], [[4qua]], [[4qub]] [[4qud]], [[4que]], [[4qug]], [[4quh]], [[4qui]], [[4quj]], [[4qul]], [[5i9b]], [[5i9t]], [[5iab]], [[5iae]], [[5iag]], [[5iaj]], [[5iak]], [[5ian]], [[5iar]], [[5ias]], [[5ibc]], [[5ibp]], [[5ibr]], [[4qud]], [[6bfj]], [[6bfk]], [[6bfl]], [[6bfo]], [[6bg0]], [[6bg1]], [[6bg4]], [[6bgk]], [[6bgq]], [[6bgr]], [[6bgs]], [[6bh9]], [[6bha]], [[6bdv]] - hCASP (mutant) + polypeptide inhibitor<br />
**[[2cjx]], [[2cjy]], [[2dko]], [[4qtx]], [[4qty]], [[4qu0]], [[4qu5]], [[4qu8]], [[4qu9]], [[4qua]], [[4qub]] [[4qud]], [[4qud]], [[4que]], [[4qug]], [[4quh]], [[4qui]], [[4quj]], [[4qul]], [[5i9b]], [[5i9t]], [[5iab]], [[5iae]], [[5iag]], [[5iaj]], [[5iak]], [[5ian]], [[5iar]], [[5ias]], [[5ibc]], [[5ibp]], [[5ibr]], [[6bdv]], [[6bfj]], [[6bfk]], [[6bfl]], [[6bfo]], [[6bg0]], [[6bg1]], [[6bg4]], [[6bgk]], [[6bgq]], [[6bgr]], [[6bgs]], [[6bh9]], [[6bha]] - hCASP (mutant) + polypeptide inhibitor<br />
**[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br />
**[[1gfw]], [[1nme]], [[1nmq]], [[1nms]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[3h0e]], [[3kjf]] – hCASP + inhibitor<br />
**[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br />
**[[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[3itn]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br />
**[[4jqy]], [[4jqz]] - hpro-CASP (mutant)<br />
**[[4jqy]], [[4jqz]] - hpro-CASP (mutant)<br />
**[[1i3o]] - hCASP (mutant) + XIAP-BIR2<br />
**[[1i3o]] - hCASP (mutant) + XIAP-BIR2<br />
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*CASP-6
*CASP-6


**[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br />
**[[2wdp]], [[3k7e]], [[3p45]] – hCASP<br />
**[[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]], [[4iyr]], [[6dev]], [[6deu]] – hCASP (mutant) <br />
**[[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]], [[4iyr]], [[6deu]], [[6dev]] – hCASP (mutant) <br />
**[[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br />
**[[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br />
**[[4ejf]] – hCASP subunit P11 + P18 + polypeptide<br />
**[[4ejf]] – hCASP subunit P11 + P18 + polypeptide<br />
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**[[3ibf]] – hCASP large subunit<br />  
**[[3ibf]] – hCASP large subunit<br />  
**[[3r5k]], [[4hq0]] - hCASP (mutant) <br />
**[[3r5k]], [[4hq0]] - hCASP (mutant) <br />
**[[1k86]], [[1gqf]] – hCASP catalytic domain<br />
**[[1gqf]], [[1k86]] – hCASP catalytic domain<br />
**[[1k88]] – hpro-CASP (mutant) <br />
**[[1k88]] – hpro-CASP (mutant) <br />
**[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP large subunit + polypeptide inhibitor<br />
**[[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]], [[3ibc]] - hCASP large subunit + polypeptide inhibitor<br />
**[[1f1j]], [[4hqr]] - hCASP + polypeptide inhibitor<br />
**[[1f1j]], [[4hqr]] - hCASP + polypeptide inhibitor<br />
**[[7wzs]] – hCASP + calmodulin + CopC <br />
**[[7wzs]] – hCASP + calmodulin + CopC <br />
**[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br />
**[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br />
**[[1shj]], [[1shl]] - hCASP catalytic domain (mutant) + inhibitor<br />
**[[1shj]], [[1shl]] - hCASP catalytic domain (mutant) + inhibitor<br />
**[[4fea]], [[5v6z]], [[5v6u]] - hCASP catalytic domain + inhibitor<br />
**[[4fea]], [[5v6u]], [[5v6z]] - hCASP catalytic domain + inhibitor<br />
**[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br />
**[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br />
**[[1i4o]] - hCASP P20 subunit + XIAP<br />
**[[1i4o]] - hCASP P20 subunit + XIAP<br />
**[[4jb8]], [[4lsz]] - hCASP large+small subunits + DARPIN<br />
**[[4jb8]], [[4lsz]] - hCASP large+small subunits + DARPIN<br />
**[[5ic6]], [[5ic4]], [[4zvo]], [[4zvp]], [[4zvq]], [[4zvr]], [[4zvs]], [[4zvt]], [[4zvu]], [[6cl2]], [[6cl1]], [[6cl0]] - hCASP large+small subunits + peptide inhibitor<br />
**[[4zvo]], [[4zvp]], [[4zvq]], [[4zvr]], [[4zvs]], [[4zvt]], [[4zvu]], [[5ic6]], [[5ic4]], [[6cl0]], [[6cl1]], [[6cl2]] - hCASP large+small subunits + peptide inhibitor<br />


*CASP-8
*CASP-8
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**[[6xkj]] – hCASP CARD domain 451-537 – Cryo-EM<br />
**[[6xkj]] – hCASP CARD domain 451-537 – Cryo-EM<br />
**[[4zbw]], [[7lvj]], [[7lvm]] - hCASP death effector domain<br />
**[[4zbw]], [[7lvj]], [[7lvm]] - hCASP death effector domain<br />
**[[5h33]], [[5h31]] - hCASP death effector domain (mutant)<br />
**[[5h31]], [[5h33]] - hCASP death effector domain (mutant)<br />
**[[6agw]] - hCASP pro domain 1-180<br />
**[[6agw]] - hCASP pro domain 1-180<br />
**[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br />
**[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br />
**[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br />
**[[1f9e]], [[1qdu]], [[1qtn]] - hCASP subunit α,β + polypeptide inhibitor<br />
**[[1qtn]], [[4jj7]], [[4jj8]], [[4prz]] - hCASP P18, P11 + polypeptide inhibitor<br />
**[[1qtn]], [[4jj7]], [[4jj8]], [[4prz]] - hCASP P18, P11 + polypeptide inhibitor<br />
**[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br />
**[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br />
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**[[6px9]] - hpro-CASP catalytic domain 276-538 + inhibitor<br />
**[[6px9]] - hpro-CASP catalytic domain 276-538 + inhibitor<br />
**[[2k7z]] – hpro-CASP catalytic domain (mutant) – NMR<br />
**[[2k7z]] – hpro-CASP catalytic domain (mutant) – NMR<br />
**[[2fun]], [[1i4e]] – CASP + P35 – ''Autographa californica''
**[[1i4e]], [[2fun]] – CASP + P35 – ''Autographa californica''


*CASP-9
*CASP-9
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**[[1jxq]] - hCASP + polypeptide inhibitor<br />
**[[1jxq]] - hCASP + polypeptide inhibitor<br />
**[[3v3k]] – hCASP + effector protein<br />
**[[3v3k]] – hCASP + effector protein<br />
**[[5wve]], [[5juy]], [[5wvc]] – hCASP CARD domain + APAF-1<br />
**[[5juy]], [[5wvc]], [[5wve]] – hCASP CARD domain + APAF-1<br />
**[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br />
**[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br />
**[[3ygs]], [[4rhw]] – hpro-CASP + APAF-1 CARD
**[[3ygs]], [[4rhw]] – hpro-CASP + APAF-1 CARD
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*Metacaspase
*Metacaspase


**[[4afp]], [[4afr]], [[4afv]], [[4af8]] – MCASP (mutant) – ''Trypanosom brucei''<br />
**[[4af8]], [[4afp]], [[4afr]], [[4afv]] – MCASP (mutant) – ''Trypanosom brucei''<br />
**[[4f6o]] – yMCASP 1 – yeast<br />
**[[4f6o]] – yMCASP 1 – yeast<br />
**[[4f6p]] – yMCASP 1 (mutant)<br />
**[[4f6p]] – yMCASP 1 (mutant)<br />

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Michal Harel
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