Bromodomain-containing protein 3D structures: Difference between revisions
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**[[3s91]], [[3s92]], [[6qju]], [[7laz]] – hBRD3 bromodomain 1 + inhibitor<br /> | **[[3s91]], [[3s92]], [[6qju]], [[7laz]] – hBRD3 bromodomain 1 + inhibitor<br /> | ||
**[[7r8r]] – hBRD3 bromodomain 1 + physachenolide<br /> | **[[7r8r]] – hBRD3 bromodomain 1 + physachenolide<br /> | ||
**[[6u4a]], [[7rjk]], [[7rjl]], [[7rjm]], [[7rjn]]– hBRD3 bromodomain 1 + peptide<br /> | **[[6u4a]], [[7rjk]], [[7rjl]], [[7rjm]], [[7rjn]], [[7to7]], [[7to9]], [[7toa]] – hBRD3 bromodomain 1 + peptide<br /> | ||
**[[2oo1]] – hBRD3 bromodomain 2<br /> | **[[2oo1]] – hBRD3 bromodomain 2<br /> | ||
**[[2e7n]] – hBRD3 bromodomain 2 - NMR<br /> | **[[2e7n]] – hBRD3 bromodomain 2 - NMR<br /> | ||
**[[5hfr]] – hBRD3 bromodomain 2 (mutant)<br /> | **[[5hfr]] – hBRD3 bromodomain 2 (mutant)<br /> | ||
**[[5hjc]], [[6ulp]] – hBRD3 bromodomain 2+ | **[[5hjc]], [[6ulp]], [[8cv5]], [[8b5a]] – hBRD3 bromodomain 2+ peptide<br /> | ||
**[[5a7c]] – hBRD3 bromodomain 2 + inhibitor<br /> | **[[5a7c]], [[7l9l]], [[7lb4]], [[7s3p]], [[7ug5]] – hBRD3 bromodomain 2 + inhibitor<br /> | ||
**[[7jmy]] – hBRD3 ET domain - NMR<br /> | **[[7jmy]] – hBRD3 ET domain - NMR<br /> | ||
**[[6bgg]], [[6bgh]], [[7jq8]], [[7jyn]], [[7jyz]] – hBRD3 ET domain + peptide - NMR<br /> | **[[6bgg]], [[6bgh]], [[7jq8]], [[7jyn]], [[7jyz]] – hBRD3 ET domain + peptide - NMR<br /> | ||
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*Bromodomain-containing protein 4 | *Bromodomain-containing protein 4 | ||
**[[2oss]], [[4j3i]], [[4lyi]], [[5hq7]], [[5hq6]], [[5hq5]] – hBRD4 bromodomain 1<br /> | **[[2oss]], [[4j3i]], [[4lyi]], [[5hq7]], [[5hq6]], [[5hq5]], [[8ibq]] – hBRD4 bromodomain 1<br /> | ||
**[[2ouo]] – hBRD4 bromodomain 2<br /> | **[[2ouo]] – hBRD4 bromodomain 2<br /> | ||
**[[2i8n]] – hBRD4 bromodomain 2 - NMR<br /> | **[[2i8n]] – hBRD4 bromodomain 2 - NMR<br /> | ||
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**[[6dne]] – hBRD4 + inhibitor<br /> | **[[6dne]] – hBRD4 + inhibitor<br /> | ||
**[[8ov6]] – hBRD4 + DCAF16 + DDB1 - Cryo EM<br /> | |||
**[[8g46]] – hBRD4 + DCAF16 + DDB1 + DET1 - Cryo EM<br /> | |||
*Bromodomain-containing protein 4 bromodomain 1 residues 44-168 complex | *Bromodomain-containing protein 4 bromodomain 1 residues 44-168 complex | ||
**[[3p5o]], [[ | **[[2yel]], [[3p5o]], [[3svf]], [[3svg]], [[3u5j]], [[3u5k]], [[3u5l]], [[3zyu]], [[4a9l]], [[4bjx]], [[4bw1]], [[4bw2]], [[4bw3]], [[4bw4]], [[4c66]], [[4c67]], [[4cfk]], [[4cfl]], [[4cl9]], [[4clb]], [[4don]], [[4e96]], [[4f3i]], [[4gpj]], [[4hxk]], [[4hxl]], [[4hxm]], [[4hxn]], [[4hxo]], [[4hxp]], [[4hxr]], [[4hxs]], [[4hbv]], [[4hbw]], [[4hbx]], [[4hby]], [[4ioo]], [[4ioq]], [[4ior]], [[4j0r]], [[4j0s]], [[4lr6]], [[4lrg]], [[4lyw]], [[4lzs]], [[4men]], [[4meo]], [[4mep]], [[4meq]], [[4mr3]], [[4mr4]], [[4nqm]], [[4nr8]], [[4nuc]], [[4nue]], [[4nud]], [[4o70]], [[4o71]], [[4o72]], [[4o74]], [[4o75]], [[4o76]], [[4o77]], [[4o78]], [[4o7a]], [[4o7b]], [[4o7c]], [[4o7e]], [[4o7f]], [[4ogi]], [[4ogj]], [[4pce]], [[4pci]], [[4ps5]], [[4qr3]], [[4qr4]], [[4qr5]], [[4qzs]], [[4uix]], [[4uiy]], [[4uiz]], [[4uyd]], [[4wiv]], [[4x2i]], [[4xy9]], [[4xya]], [[4yh3]], [[4yh4]], [[4z1q]], [[4z1s]], [[4zc9]], [[4zw1]], [[5a5s]], [[5a85]], [[5acy]], [[5ad2]], [[5ad3]], [[5bt4]], [[5cfw]], [[5coi]], [[5cp5]], [[5cpe]], [[5cqt]], [[5crm]], [[5crz]], [[5cs8]], [[5ctl]], [[5cy9]], [[5d0c]], [[5d24]], [[5d25]], [[5d26]], [[5d3h]], [[5d3j]], [[5d3l]], [[5d3n]], [[5d3p]], [[5d3r]], [[5d3s]], [[5d3t]], [[5dlx]], [[5dlz]], [[5dw2]], [[5dx4]], [[5e0r]], [[5egu]], [[5ei4]], [[5eis]], [[5f5z]], [[5f60]], [[5f61]], [[5f62]], [[5f63]], [[5fbx]], [[5h21]], [[5hls]], [[5hm0]], [[5kdh]], [[5kj0]], [[5ku3]], [[5khm]], [[5i80]], [[5i88]], [[5lj1]], [[5lj2]], [[5lrq]], [[5luu]], [[5m39]], [[5m3a]], [[5mkz]], [[5mli]], [[5n2m]], [[5o97]], [[5ovb]], [[5ti7]], [[5u2f]], [[5u2e]], [[5u28]], [[5ula]], [[5v67]], [[5vom]], [[5uvw]], [[5vbo]], [[5vbp]], [[5vzs]], [[5w55]], [[5wa5]], [[5wma]], [[5wuu]], [[5xhy]], [[5xi2]], [[5xi3]], [[5xi4]], [[5y1y]], [[5y93]], [[5y94]], [[5y8c]], [[5y8w]], [[5y8y]], [[5y8z]], [[5yqx]], [[5z1r]], [[5z1s]], [[5z1t]], [[5z5t]], [[5z5u]], [[5z5v]], [[5z8g]], [[5z8r]], [[5z8z]], [[5z90]], [[5z9k]], [[6afr]], [[6ajv]], [[6ajw]], [[6ajx]], [[6ajy]], [[6cd4]], [[6cd5]], [[6cis]], [[6ciy]], [[6cj1]], [[6cj2]], [[6ckr]], [[6cks]], [[6czu]], [[6czv]], [[6djc]], [[6dl2]], [[6dmj]], [[6dml]], [[6e4a]], [[6fnx]], [[6fo5]], [[6fsy]], [[6ft3]], [[6ft4]], [[6hdq]], [[6i7x]], [[67iy]], [[6in1]], [[6in2]], [[6ji3]], [[6ji4]], [[6ji5]], [[6jj3]], [[6jj5]], [[6jj6]], [[6jjb]], [[6kec]], [[6ked]], [[6kee]], [[6kef]], [[6keg]], [[6keh]], [[6kei]], [[6kej]], [[6kek]], [[6lg4]], [[6lg5]], [[6lg6]], [[6lg7]], [[6lg8]], [[6lg9]], [[6lih]], [[6lim]], [[6mau]], [[6mh1]], [[6mh7]], [[6p05]], [[6prt]], [[6ps9]], [[6psb]], [[6q3y]], [[6q3z]], [[6rwj]], [[6s25]], [[6s4b]], [[6s6k]], [[6sb8]], [[6se4]], [[6swn]], [[6swq]], [[6tpx]], [[6tpy]], [[6tpz]], [[6tq1]], [[6u0d]], [[6uvj]], [[6uvm]], [[6uwu]], [[6uwx]], [[6v0u]], [[6v1k]], [[6v1l]], [[6v1u]], [[6viw]], [[6vix]], [[6viz]], [[6vub]], [[6vuc]], [[6vuf]], [[6vuj]], [[6wgx]], [[6ww8]], [[6x7b]], [[6x7c]], [[6x7d]], [[6xv7]], [[6xvc]], [[6wvx]], [[6yin]], [[6yqn]], [[6yqo]], [[6yqp]], [[6z7g]], [[6z7l]], [[6z7m]], [[6zci]], [[6zed]], [[6zel]], [[6zf9]], [[7c2z]], [[7a9u]], [[7ajn]], [[7axr]], [[7b1t]], [[7c6p]], [[7dhs]], [[7ehw]], [[7ehy]], [[7eig]], [[7eik]], [[7eil]], [[7fh2]], [[7k6g]], [[7k6h]], [[7khl]], [[7kkw]], [[7jkw]], [[7jkx]], [[7jky]], [[7l9m]], [[7la9]], [[7lh8]], [[7m16]], [[7mce]], [[7mcf]], [[7mlq]], [[7mlr]], [[7mls]], [[7mr5]], [[7mr6]], [[7mr7]], [[7mr8]], [[7mr9]], [[7mra]], [[7mrb]], [[7rn2]], [[7o18]], [[7oeo]], [[7p6v]], [[7p6w]], [[7p6y]], [[7q3f]], [[7qdl]], [[7r5b]], [[7r9c]], [[7rek]], [[7rel]], [[7rem]], [[7rmd]], [[7rui]], [[7rxr]], [[7rxs]], [[7rxt]], [[7t3f]], [[7ugf]], [[7uty]], [[7uzn]], [[7v1u]], [[7v2j]], [[7w3d]], [[7wjs]], [[7wky]], [[7wl4]], [[7wwz]], [[7x6t]], [[6xuz]], [[7yl2]], [[7ymg]], [[7yq9]], [[8b96]], [[8b98]], [[8c11]], [[8ckf]], [[8dyr]], [[8e17]], [[8e3w]], [[8ead]], [[8fvk]], [[8gpz]], [[8gq0]], [[8k14]], [[8p9f]], [[8p9g]], [[8p9h]], [[8p9i]], [[8p9j]], [[8p9k]], [[8p9l]], [[8piq]], [[8pxa]], [[8pxm]], [[8pxn]], [[8q34]], [[8qal]], [[8qan]], [[8qap]], [[8qar]], [[8v9f]], [[8wiu]], [[8wqo]], [[8wxy]], [[8wy3]], [[8wy7]], [[8wyp]], [[9f1j]], [[9f1k]], [[9f1l]], [[9f1m]], [[9f1n]], [[9fwx]], [[9fxp]] – hBRD4 bromodomain 1 + inhibitor<br /> | ||
**[[5ti6]], [[5ti5]], [[5ti4]], [[5ti3]], [[5ti2]], [[5you]], [[5yov]], [[5wmd]], [[5wmg]], [[6g0d]], [[6g0e]], [[6g0f]], [[6g0g]], [[6g0h]], [[6hov]] – hBRD4 bromodomain 1 (mutant) + inhibitor<br /> | **[[5ti6]], [[5ti5]], [[5ti4]], [[5ti3]], [[5ti2]], [[5you]], [[5yov]], [[5wmd]], [[5wmg]], [[6g0d]], [[6g0e]], [[6g0f]], [[6g0g]], [[6g0h]], [[6hov]] – hBRD4 bromodomain 1 (mutant) + inhibitor<br /> | ||
**[[7z9w]], [[7z9y]], [[7za6]], [[7za7]], [[7za8]], [[7za9]], [[7zaa]], [[7zad]], [[7zae]], [[7zaj]], [[7zaq]], [[7zar]], [[7zat]], [[7ze6]], [[7ze7]], [[7zef]], [[7zen]], [[7zfn]], [[7zfo]], [[7zfs]], [[7zft]], [[7zfu]], [[7zfv]], [[7zfy]], [[7zfz]], [[7zg1]], [[7zg2]] – hBRD4 bromodomain 1 + FragLite<br /> | |||
**[[5z9c]] – hBRD4 bromodomain 1 + inhibitor - NMR<br /> | **[[5z9c]] – hBRD4 bromodomain 1 + inhibitor - NMR<br /> | ||
**[[4lys]], [[4lzr]], [[6ajz]] – hBRD4 bromodomain 1 + colchiceine<br /> | **[[4lys]], [[4lzr]], [[6ajz]] – hBRD4 bromodomain 1 + colchiceine<br /> | ||
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**[[6u6k]], [[6u72]], [[6u74]], [[6u8m]], [[6uls]], [[6ulv]] – hBRD4 bromodomain 1 + cyclic peptide<br /> | **[[6u6k]], [[6u72]], [[6u74]], [[6u8m]], [[6uls]], [[6ulv]] – hBRD4 bromodomain 1 + cyclic peptide<br /> | ||
**[[6bn7]], [[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hBRD4 bromodomain 1 (mutant) + DNA damage-binding protein + cereblon<br /> | **[[6bn7]], [[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hBRD4 bromodomain 1 (mutant) + DNA damage-binding protein + cereblon<br /> | ||
**[[7khh]], [[7znt]] – hBRD4 bromodomain 1 + elongin-B + elongin-C + PVHL peptide + inhibitor<br /> | **[[7khh]], [[7znt]], [[8bds]], [[8beb]] – hBRD4 bromodomain 1 + elongin-B + elongin-C + PVHL peptide + inhibitor<br /> | ||
**[[3uvw]], [[3uvy]], [[3uvx]], [[3uw9]] – hBRD4 bromodomain 1 + histone H4 peptide<br /> | **[[3uvw]], [[3uvy]], [[3uvx]], [[3uw9]], [[8b5b]], [[8b5c]] – hBRD4 bromodomain 1 + histone H4 peptide<br /> | ||
**[[7tuq]], [[7tv0]] – hBRD4 bromodomain 1 + SARS peptide<br /> | **[[7tuq]], [[7tv0]] – hBRD4 bromodomain 1 + SARS peptide<br /> | ||
**[[4kv1]], [[5nng]], [[5nnf]], [[5nne]], [[5nng]], [[5nnf]], [[5nne]], [[7rjo]], [[7rjp]], [[7rjq]], [[7rjr]] – hBRD4 bromodomain 1 + peptide<br /> | **[[4kv1]], [[5nng]], [[5nnf]], [[5nne]], [[5nng]], [[5nnf]], [[5nne]], [[6g0o]], [[6g0p]], [[7rjo]], [[7rjp]], [[7rjq]], [[7rjr]], [[7to8]] – hBRD4 bromodomain 1 + peptide<br /> | ||
**[[8ewv]] – hBRD4 bromodomain 1 + elongin-B + elongin-C + PVHL peptide<br /> | |||
**[[6bnh]] – hBRD4 ET domain + JMJD6 peptide - NMR<br /> | **[[6bnh]] – hBRD4 ET domain + JMJD6 peptide - NMR<br /> | ||
**[[3mxf]] – mBRD4 bromodomain 1 + inhibitor<br /> | **[[3mxf]] – mBRD4 bromodomain 1 + inhibitor<br /> | ||
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*Bromodomain-containing protein 4 bromodomain 2 residues 344-455 complex | *Bromodomain-containing protein 4 bromodomain 2 residues 344-455 complex | ||
**[[2yem]], [[4z93]], [[5u2c]], [[5jwm]], [[5uvz]], [[5uvy]], [[5uvx]], [[5uvv]], [[5uvu]], [[5uvt]], [[5uvs]], [[5uoo]], [[5uf0]], [[5uez]], [[5uey]], [[5uex]], [[5uew]], [[5uev]], [[5ueu]], [[5uet]], [[5ues]], [[5uer]], [[5ueq]], [[5uep]], [[5ueo]], [[6ffd]], [[6ffe]], [[6ffg]], [[6c7q]], [[6c7r]], [[6duv]], [[6i80]], [[6i81]], [[6zb3]], [[7c6p]], [[7jkz]], [[7ko0]], [[7ruh]] – hBRD4 bromodomain 2 + inhibitor<br /> | **[[7usk]] – hBRD4 bromodomain 2 <br /> | ||
**[[2yem]], [[4z93]], [[5u2c]], [[5jwm]], [[5uvz]], [[5uvy]], [[5uvx]], [[5uvv]], [[5uvu]], [[5uvt]], [[5uvs]], [[5uoo]], [[5uf0]], [[5uez]], [[5uey]], [[5uex]], [[5uew]], [[5uev]], [[5ueu]], [[5uet]], [[5ues]], [[5uer]], [[5ueq]], [[5uep]], [[5ueo]], [[6ffd]], [[6ffe]], [[6ffg]], [[6c7q]], [[6c7r]], [[6duv]], [[6i80]], [[6i81]], [[6zb3]], [[7c6p]], [[7jkz]], [[7ko0]], [[7ruh]], [[7ush]], [[7usj]], [[8idh]], [[8zmq]], [[9fby]] – hBRD4 bromodomain 2 + inhibitor<br /> | |||
**[[7aqt]] – hBRD4 bromodomain 2 + inhibitor - NMR<br /> | **[[7aqt]] – hBRD4 bromodomain 2 + inhibitor - NMR<br /> | ||
**[[2lsp]] – hBRD4 bromodomain 2 + Nf-Kb peptide<br /> | **[[2lsp]] – hBRD4 bromodomain 2 + Nf-Kb peptide<br /> | ||
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**[[6mnl]] – hBRD4 bromodomain 2 + foxo3a peptide<br /> | **[[6mnl]] – hBRD4 bromodomain 2 + foxo3a peptide<br /> | ||
**[[6ko2]] – hBRD4 bromodomain 2 + histone peptide<br /> | **[[6ko2]] – hBRD4 bromodomain 2 + histone peptide<br /> | ||
**[[6u6l]], [[6u8g]], [[6u8i]] – hBRD4 bromodomain 2 + cyclic peptide<br /> | **[[6u6l]], [[6u8g]], [[6u8i]] – hBRD4 bromodomain 2 + cyclic peptide<br /> | ||
**[[ | **[[5t35]], [[6sis]], [[8bdt]], [[8bdx]] – hBRD4 bromodomain 2 + elongin-B + elongin-C + PVHL peptide<br /> | ||
**[[8rwz]] – hBRD4 bromodomain 2 + elongin-B + elongin-C + PVHL peptide + cullin + RBX1 – Cryo EM<br /> | |||
**[[8r5h]] – hBRD4 bromodomain 2 in cullin ring ligase – Cryo EM<br /> | |||
*Bromodomain-containing protein 7 | *Bromodomain-containing protein 7 | ||
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**[[6ppa]] – hBRD7 bromodomain <br /> | **[[6ppa]] – hBRD7 bromodomain <br /> | ||
**[[5mq1]], [[6v0q]], [[6v16]], [[6v17]], [[6v1e]], [[6v1f]], [[6v1h]] – hBRD7 bromodomain + inhibitor<br /> | **[[5mq1]], [[6v0q]], [[6v16]], [[6v17]], [[6v1e]], [[6v1f]], [[6v1h]] – hBRD7 bromodomain + inhibitor<br /> | ||
**[[7y84]] – hBRD7 in nucleosome PBAF complex – Cryo EM<br /> | |||
*Bromodomain-containing protein 9 | *Bromodomain-containing protein 9 | ||
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**[[5igm]] – hBRD9 bromodomain + bromosporine <br /> | **[[5igm]] – hBRD9 bromodomain + bromosporine <br /> | ||
**[[6v0x]] – hBRD9 bromodomain + sunitinib <br /> | **[[6v0x]] – hBRD9 bromodomain + sunitinib <br /> | ||
**[[4nqn]], [[4xy8]], [[4z6h]], [[4z6i]], [[5e9v]], [[5f2p]], [[5f25]], [[5f1l]], [[5f1h]], [[5eu1]], [[5mky]], [[6hm0]], [[6bqa]], [[6v0s]], [[6v14]], [[6v1b]], [[6y7h]], [[6y7j]], [[6y7k]], [[6y7i]], [[6y7l]], [[6yqr]], [[6yqs]], [6yqw]], [[6yqz]], [[8a71]] – hBRD9 bromodomain + inhibitor<br /> | **[[4nqn]], [[4xy8]], [[4z6h]], [[4z6i]], [[5e9v]], [[5f2p]], [[5f25]], [[5f1l]], [[5f1h]], [[5eu1]], [[5mky]], [[6hm0]], [[6bqa]], [[6v0s]], [[6v14]], [[6v1b]], [[6y7h]], [[6y7j]], [[6y7k]], [[6y7i]], [[6y7l]], [[6yqr]], [[6yqs]], [[6yqw]], [[6yqz]], [[8a71]], [[8a7i]], [[8ahc]] – hBRD9 bromodomain + inhibitor<br /> | ||
**[[4yy4]] – hBRD9 bromodomain + DMSO<br /> | **[[4yy4]] – hBRD9 bromodomain + DMSO<br /> | ||
**[[4yy6]], [[4yyd]], [[4yyg]], [[4yyh]], [[4yyj]], [[4yyk]], [[4yyi]] – hBRD9 bromodomain + histone H4 peptide<br /> | **[[4yy6]], [[4yyd]], [[4yyg]], [[4yyh]], [[4yyj]], [[4yyk]], [[4yyi]] – hBRD9 bromodomain + histone H4 peptide<br /> | ||