Synaptotagmin: Difference between revisions

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 '''Synaptotagmin''' (SYT) are calcium-binding proteins which are conserved from nematodes to humans.  Fifteen SYTs have been identified in mammals<ref>PMID:18468511</ref>. '''Synaptotagmin-1''' (SYT1) is a synaptic vesicle membrane protein and is a sensor which induces release in neurons upon binding of Ca+2 ions<ref>PMID:19412166</ref>.  The C2A domain of SYT binds phospholipids in Ca+2-dependent manner<ref>PMID:9730811</ref>.  The C2B domain of SYT promotes binding to other C2B domains and to accessory proteins.  Ca+2 binding causes intramolecular association of domains C2A and C2B.  The synaptic fusion apparatus includes the affinity between SYT and [[Syntaxin]]-1,  This affinity increases by ca. 2 orders of magnitude upon binding of Ca+2<ref>PMID:7559535</ref>.
-'''Synaptotagmin-like proteins''' (SYTL) are required in a generation of a single apical surface per cell<ref>PMID:22820376</ref>.
+*'''Synaptotagmin-2''' is a Ca+2 sensor for fast neurotransmitter release in caudal brain regions<ref>PMID:17192432</ref>.
+*'''Synaptotagmin-like proteins''' (SYTL) are required in a generation of a single apical surface per cell<ref>PMID:22820376</ref>.
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