Cysteine desulfurase: Difference between revisions
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== Function == | == Function == | ||
'''Cysteine desulfurase''' ( | '''Cysteine desulfurase''' (Suf) catalyzes the conversion of L-cysteine to L-alanine and sulfane sulfur. Suf has a role in the biosynthesis of Fe-S custers, thiamine, thionucleosides, biotin, lipoic acid, molybdopterin and NAD<ref>PMID:12382038</ref>. Suf is a PLP-dependent enzyme. | ||
== Structural highlights == | == Structural highlights == | ||
The structure of | The structure of SufS contains the <scene name='80/800705/Cv/2'>cofactor PLP bound to Lys224</scene>. | ||
*<scene name='80/800705/Cv/4'>All interactions of PLP</scene>. | *<scene name='80/800705/Cv/4'>All interactions of PLP</scene>. | ||
<scene name='80/800705/Cv/5'>Cys361 is the nucleophilic catalytic residue</scene>. The reaction product <scene name='80/800705/Cv/6'>alanine is bound near the Cys361-persulfide</scene><ref>PMID:27382962</ref>. | <scene name='80/800705/Cv/5'>Cys361 is the nucleophilic catalytic residue</scene>. The reaction product <scene name='80/800705/Cv/6'>alanine is bound near the Cys361-persulfide</scene><ref>PMID:27382962</ref>. | ||