Polycomb proteins: Difference between revisions

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 '''Polycomb group (PcG) proteins''' are determinants of gene silencing and epigenetic memory in higher eukaryotes.  The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures.  The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth<ref>PMID:27705803</ref>.  For the '''B'''-cell-specific '''M'''olony leukemia virus '''I'''nsertion site '''1''' (BMI1) see [[BMI1]].
-*'''Pcgf5''' is required in the differentiation of embryonic stem cells toward neural cells<ref>PMID:29765032</ref>.
+*'''Pcgf5''' and '''Polycomb SUZ12''' are required in the differentiation of embryonic stem cells toward neural cells<ref>PMID:29765032</ref>, <ref>PMID:17339329</ref>.
 *'''Pcgf6''' has a critical role in safeguarding lineage decisions and in preventing aberrant expression of germ cell-related genes<ref>PMID:32482889</ref>.
 *'''Polycomb EED''' is a component of Polycomb repressive complex 2 (PRC2) and is an epigenetic exchange factor coordinating the activities of PRC1 and PRC2<ref>PMID:24457600</ref>.