6hga: Difference between revisions

<table><tr><td colspan='2'>[[6hga]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HGA FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hga OCA], [https://pdbe.org/6hga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hga RCSB], [https://www.ebi.ac.uk/pdbsum/6hga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hga ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/I17RC_HUMAN I17RC_HUMAN] Chronic mucocutaneous candidiasis. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/I17RC_HUMAN I17RC_HUMAN] Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).<ref>PMID:16785495</ref> <ref>PMID:17911633</ref> <ref>PMID:18684971</ref>  Receptor for both IL17A and IL17F.<ref>PMID:16785495</ref>  Does not bind IL17A or IL17F.<ref>PMID:16785495</ref>  Does not bind IL17A or IL17F.<ref>PMID:16785495</ref>  Receptor for both IL17A and IL17F.<ref>PMID:16785495</ref>  

[[Category: Homo sapiens]]

[[Category: Mus musculus]]

[[Category: Goepfert A]]

[[Category: Rondeau JM]]