5z1c: Difference between revisions
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<table><tr><td colspan='2'>[[5z1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z1C FirstGlance]. <br> | <table><tr><td colspan='2'>[[5z1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z1C FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZXI: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZXI:(4-iodophenyl)methanamine'>ZXI</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z1c OCA], [https://pdbe.org/5z1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z1c RCSB], [https://www.ebi.ac.uk/pdbsum/5z1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z1c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z1c OCA], [https://pdbe.org/5z1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z1c RCSB], [https://www.ebi.ac.uk/pdbsum/5z1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z1c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 12:39, 23 October 2024
The crystal structure of uPA in complex with 4-Iodobenzylamine at pH7.4The crystal structure of uPA in complex with 4-Iodobenzylamine at pH7.4
Structural highlights
DiseaseUROK_HUMAN Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:601709. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.[1] FunctionUROK_HUMAN Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. See AlsoReferences
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