6fd3: Difference between revisions

<table><tr><td colspan='2'>[[6fd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FD3 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T8L:(2~{S},3~{R})-2-azanyl-3-[oxidanyl(sulfanyl)phosphoryl]oxy-butanoic+acid'>T8L</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fd3 OCA], [https://pdbe.org/6fd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fd3 RCSB], [https://www.ebi.ac.uk/pdbsum/6fd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fd3 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PAK3_HUMAN PAK3_HUMAN] X-linked non-syndromic intellectual disability. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/PAK3_HUMAN PAK3_HUMAN] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.<ref>PMID:21177870</ref>  

*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Bountra C]]

[[Category: Edwards AM]]

[[Category: Elkins JM]]

[[Category: Sorrell FJ]]

[[Category: Wang D]]

[[Category: Von Delft F]]