6fax: Difference between revisions

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==Complex of Human CD40 Ectodomain with Lob 7.4 Fab==
==Complex of Human CD40 Ectodomain with Lob 7.4 Fab==
<StructureSection load='6fax' size='340' side='right' caption='[[6fax]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
<StructureSection load='6fax' size='340' side='right'caption='[[6fax]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fax]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FAX FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fax]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FAX FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD40, TNFRSF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fax OCA], [http://pdbe.org/6fax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fax RCSB], [http://www.ebi.ac.uk/pdbsum/6fax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fax ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fax OCA], [https://pdbe.org/6fax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fax RCSB], [https://www.ebi.ac.uk/pdbsum/6fax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fax ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:[http://omim.org/entry/606843 606843]]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:11675497</ref>
[https://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:[https://omim.org/entry/606843 606843]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:11675497</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Receptor for TNFSF5/CD40LG.  
[https://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN] Receptor for TNFSF5/CD40LG.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6fax" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fax" style="background-color:#fffaf0;"></div>
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Orr, C M]]
[[Category: Large Structures]]
[[Category: Pearson, A R]]
[[Category: Orr CM]]
[[Category: Tews, I]]
[[Category: Pearson AR]]
[[Category: Agonist]]
[[Category: Tews I]]
[[Category: Cd40]]
[[Category: Engineered fab]]
[[Category: Immune system]]
[[Category: Mab]]

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