6f02: Difference between revisions

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==Crystal structure of human glycosylated kallistatin at 3.0 Angstrom resolution==
==Crystal structure of human glycosylated kallistatin at 3.0 Angstrom resolution==
<StructureSection load='6f02' size='340' side='right' caption='[[6f02]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='6f02' size='340' side='right'caption='[[6f02]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6f02]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F02 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6f02]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F02 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f02 OCA], [http://pdbe.org/6f02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f02 RCSB], [http://www.ebi.ac.uk/pdbsum/6f02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f02 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f02 OCA], [https://pdbe.org/6f02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f02 RCSB], [https://www.ebi.ac.uk/pdbsum/6f02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f02 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KAIN_HUMAN KAIN_HUMAN]] Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.<ref>PMID:8227002</ref>
[https://www.uniprot.org/uniprot/KAIN_HUMAN KAIN_HUMAN] Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.<ref>PMID:8227002</ref>  
 
==See Also==
*[[Serpin 3D structures|Serpin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ma, L]]
[[Category: Homo sapiens]]
[[Category: Zhou, A]]
[[Category: Large Structures]]
[[Category: Heparin]]
[[Category: Ma L]]
[[Category: Hydrolase]]
[[Category: Zhou A]]
[[Category: Inhibitor]]
[[Category: Kallilrein]]
[[Category: Protease]]
[[Category: Serine protease inhibitor]]

Latest revision as of 08:12, 21 November 2024

Crystal structure of human glycosylated kallistatin at 3.0 Angstrom resolutionCrystal structure of human glycosylated kallistatin at 3.0 Angstrom resolution

Structural highlights

6f02 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KAIN_HUMAN Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.[1]

See Also

References

  1. ↑ Chai KX, Chen LM, Chao J, Chao L. Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli. J Biol Chem. 1993 Nov 15;268(32):24498-505. PMID:8227002

6f02, resolution 3.00Å

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