Monocyte chemoattractant protein: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 15: | Line 15: | ||
It exists as a monomer or a dimer, even though the homodimer form is preferred. | It exists as a monomer or a dimer, even though the homodimer form is preferred. | ||
The structure of the monomer is made of <scene name='72/721520/Ligand_binding_on_ccl2/2'>3 Beta sheets and 1 alpha helix</scene>. | The structure of the monomer is made of <scene name='72/721520/Ligand_binding_on_ccl2/2'>3 Beta sheets and 1 alpha helix</scene>. | ||
*'''MCP-4''' is a potent chemoattractant for monocytes and eosinophils and stimulates histamine release from basophils<ref>PMID:8955214</ref>. | |||
== Ligands == | == Ligands == | ||
The known ligands for CCL2 are <scene name='72/721520/Ligand_binding_on_ccl2/1'>Potassium and PO4</scene>. The potassium binds to the S33 and S34 of the monomer and PO4 binds to F15 and N17. | The known ligands for CCL2 are <scene name='72/721520/Ligand_binding_on_ccl2/1'>Potassium and PO4</scene>. The potassium binds to the S33 and S34 of the monomer and PO4 binds to F15 and N17. | ||