1tdt: Difference between revisions

Revision as of 09:49, 3 May 2008

THREE-DIMENSIONAL STRUCTURE OF TETRAHYDRODIPICOLINATE-N-SUCCINLYTRANSFERASE

OverviewOverview

The conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA is catalyzed by tetrahydrodipicolinate N-succinyltransferase and is the committed step in the succinylase pathway by which bacteria synthesize L-lysine and meso-diaminopimelate, a component of peptidoglycan. The X-ray crystal structure of THDP succinyltransferase has been determined to 2.2 A resolution and has been refined to a crystallographic R-factor of 17.0%. The enzyme is trimeric and displays the left-handed parallel beta-helix (L beta H) structural motif encoded by the "hexapeptide repeat" amino acid sequence motif [Raetz, C.R.H., & Roderick, S.L. (1995) Science 270, 997-1000]. The approximate location of the active site of THDP succinyltransferase is suggested by the proximity of binding sites for two inhibitors: p-(chloromercuri)benzenesulfonic acid and cobalt ion, both of which bind to the L beta H domain.

About this StructureAbout this Structure

1TDT is a Single protein structure of sequence from Mycobacterium bovis. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional structure of tetrahydrodipicolinate N-succinyltransferase., Beaman TW, Binder DA, Blanchard JS, Roderick SL, Biochemistry. 1997 Jan 21;36(3):489-94. PMID:9012664 Page seeded by OCA on Sat May 3 09:49:57 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1tdt.gif|left|200px]]
- {{Structure
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 '''THREE-DIMENSIONAL STRUCTURE OF TETRAHYDRODIPICOLINATE-N-SUCCINLYTRANSFERASE'''
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 [[Category: Blanchard, J S.]]
 [[Category: Roderick, S L.]]
-[[Category: cell wall biosynthesis]]
+[[Category: Cell wall biosynthesis]]
-[[Category: hexapeptide transferase]]
+[[Category: Hexapeptide transferase]]
-[[Category: lysine metabolism]]
+[[Category: Lysine metabolism]]
-[[Category: succinyltransferase]]
+[[Category: Succinyltransferase]]
-[[Category: transferase]]
+[[Category: Transferase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:49:57 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:54:41 2008''