6i2y: Difference between revisions

<StructureSection load='6i2y' size='340' side='right'caption='[[6i2y]], [[Resolution|resolution]] 2.56&Aring;' scene=''>

<table><tr><td colspan='2'>[[6i2y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I2Y FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=88Z:N-(3-FLUORO-4-{[6-METHOXY-7-(3-MORPHOLIN-4-YLPROPOXY)QUINOLIN-4-YL]OXY}PHENYL)-N-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDE'>88Z</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i2y OCA], [https://pdbe.org/6i2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i2y RCSB], [https://www.ebi.ac.uk/pdbsum/6i2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i2y ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>  

[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>  

 

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith C]]

[[Category: Berger B-T]]

[[Category: Bountra C]]

[[Category: Edwards AM]]

[[Category: Elkins JM]]

[[Category: Knapp S]]

[[Category: Oerum S]]

[[Category: Sorrell FJ]]

[[Category: Von Delft F]]