Ephrin: Difference between revisions
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*'''Ephrin-A3''' has a role in forming precise tonotropy in the auditory brainstem to ensure accurate sound discrimination<ref>PMID:34235739</ref>. | *'''Ephrin-A3''' has a role in forming precise tonotropy in the auditory brainstem to ensure accurate sound discrimination<ref>PMID:34235739</ref>. | ||
*'''Ephrin-A5''' is required for the proper guidance and mapping of retinal axons in the mammalian midbrain<ref>PMID:9491985</ref>. | *'''Ephrin-A5''' is required for the proper guidance and mapping of retinal axons in the mammalian midbrain<ref>PMID:9491985</ref>. | ||
*'''Ephrin-B1''' has a role in palatal shelf outgrowth<ref>PMID:20844017</ref>. | |||
== Disease == | == Disease == | ||
Revision as of 12:20, 18 June 2024
FunctionEphrins (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation [1]. See also Ephrin receptor, Eph/ephrin signaling pathway, Ephrin Type-A Receptor.
DiseaseEph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury. Structural highlights |
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3D structures of ephrin3D structures of ephrin
Updated on 18-June-2024
ReferencesReferences
- ↑ Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007 May;17(5):230-8. Epub 2007 Apr 8. PMID:17420126 doi:http://dx.doi.org/10.1016/j.tcb.2007.03.004
- ↑ Hoshino N, Altarshan Y, Alzein A, Fernando AM, Nguyen HT, Majewski EF, Chen VC, Rochlin MW, Yu WM. Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem. J Comp Neurol. 2021 Nov;529(16):3633-3654. PMID:34235739 doi:10.1002/cne.25213
- ↑ Frisén J, Yates PA, McLaughlin T, Friedman GC, O'Leary DD, Barbacid M. Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 1998 Feb;20(2):235-43. PMID:9491985 doi:10.1016/s0896-6273(00)80452-3
- ↑ Bush JO, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010 Sep 15;24(18):2068-80. PMID:20844017 doi:10.1101/gad.1963210
- ↑ Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A. 2010 May 26. PMID:20505120