Intercellular adhesion molecule: Difference between revisions

Revision as of 10:28, 4 July 2024

Function

Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation^[1]. ICAM contains 5 Ig-like domains.

ICAM-1 is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system.

Disease

ICAM mutation is involved in multiple sclerosis^[2].

Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code 1mq8).

Drag the structure with the mouse to rotate

3D structures of intercellular adhesion molecule3D structures of intercellular adhesion molecule

Updated on 04-July-2024

ReferencesReferences

↑ van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767
↑ Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979

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Michal Harel

[1] van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767

[2] Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979

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@@ Line 4: / Line 4: @@
 '''Intercellular adhesion molecule''' (ICAM) is part of the immunoglobulin superfamily.  ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation<ref>PMID:8834767</ref>.  ICAM contains 5 Ig-like domains.
+*'''ICAM-1''' is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system.
 == Disease ==