Exportin: Difference between revisions
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'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. <br /> | '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. <br /> | ||
*'''XPO-1''' mediates nuclear transport of cellular proteins bearing a Leu-rich nuclear export signal and of RNA<ref>PMID: | *'''XPO-1''' mediates nuclear transport of cellular proteins bearing a Leu-rich nuclear export signal and of RNA<ref>PMID:36727672</ref>.<br /> | ||
*'''XPO-4''' mediates nuclear transport of eukaryotic translation initiation factor 5A<ref>PMID:10944119</ref>.<br /> | *'''XPO-4''' mediates nuclear transport of eukaryotic translation initiation factor 5A<ref>PMID:10944119</ref>.<br /> | ||
*'''XPO-5''' mediates nuclear transport of pre-miroRNAs and short hairpin RNAs<ref>PMID:14681208</ref>.<br /> | *'''XPO-5''' mediates nuclear transport of pre-miroRNAs and short hairpin RNAs<ref>PMID:14681208</ref>.<br /> | ||
*'''XPO-I''' | *'''XPO-I''' <ref>PMID:17786152</ref>.<br /> | ||
==Structural highlights == | ==Structural highlights == | ||