4ogy: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ogy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ogy OCA], [https://pdbe.org/4ogy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ogy RCSB], [https://www.ebi.ac.uk/pdbsum/4ogy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ogy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ogy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ogy OCA], [https://pdbe.org/4ogy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ogy RCSB], [https://www.ebi.ac.uk/pdbsum/4ogy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ogy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ | [https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||