Colicin: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
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Colicin peptides are plasmid-encoded. The peptide is released by the cell into the area surrounding it, and then parasitises proteins present in the host cell membrane to translocate across into the host cell. Many protein-protein interactions are involved in the cell entry, and the main system is involved in the grouping of colicins into two families: Group A colicins use the [[Tol]] system to enter the host cell, and Group B use the [[Ton]] system. Once inside the host cell, the cell killing follows 1st order kinetics - ie one molecule is theoretically sufficient to kill the cell<ref> PMID: 7577966 </ref>. | Colicin peptides are plasmid-encoded. The peptide is released by the cell into the area surrounding it, and then parasitises proteins present in the host cell membrane to translocate across into the host cell. Many protein-protein interactions are involved in the cell entry, and the main system is involved in the grouping of colicins into two families: Group A colicins use the [[Tol]] system to enter the host cell, and Group B use the [[Ton]] system. Once inside the host cell, the cell killing follows 1st order kinetics - ie one molecule is theoretically sufficient to kill the cell<ref> PMID: 7577966 </ref>. | ||
*'''Colicin-A''' see [[Colicin-A]] | |||
*'''Colicin-B forms small, ion-permeable channels. It inhibits the transport of Pro and enhances the transport of methylglucoside<ref> PMID:2419320 </ref>.''' | |||
The structure of all colicins, of which over 20 have been identified, follows a 3 domain design: | The structure of all colicins, of which over 20 have been identified, follows a 3 domain design: | ||