Epidermal Growth Factor Receptor: Difference between revisions
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[[Epidermal Growth Factor Receptor]] (EGFR or '''ERBB1''') is found on the cell surface and associates to homodimers upon binding of its ligands such as the Epidermal Growth Factor (EGF) to its extracellular domain. The dimerization stimulates autophosphorylation of several tyrosine residues in the intracellular kinase domain which signal downstream transduction cascades. A human '''EGFR-2 (HER-2 or ERBB2)''' is involved in breast [[Cancer|cancer]] and is a major target for breast cancer [[Pharmaceutical Drugs|therapeutics]]. See more details in [[Herceptin - Mechanism of Action]]. '''ERBB3''' uses neuregulin as a ligand. '''ERBB4''' is a closely related [[Receptor tyrosine kinases|receptor tyrosine kinase]]. | [[Epidermal Growth Factor Receptor]] (EGFR or '''ERBB1''') is found on the cell surface and associates to homodimers upon binding of its ligands such as the Epidermal Growth Factor (EGF) to its extracellular domain. The dimerization stimulates autophosphorylation of several tyrosine residues in the intracellular kinase domain which signal downstream transduction cascades. A human '''EGFR-2 (HER-2 or ERBB2)''' is involved in breast [[Cancer|cancer]] and is a major target for breast cancer [[Pharmaceutical Drugs|therapeutics]]. See more details in [[Herceptin - Mechanism of Action]]. '''ERBB3''' uses neuregulin as a ligand. '''ERBB4''' is a closely related [[Receptor tyrosine kinases|receptor tyrosine kinase]]. | ||
See also [[Kinase-linked, enzyme-linked and related receptors]]. | See also [[Kinase-linked, enzyme-linked and related receptors]] and [[EGFR inhibitors]]. | ||
==Relevance== | ==Relevance== | ||