3al2: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3al2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3al2 OCA], [https://pdbe.org/3al2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3al2 RCSB], [https://www.ebi.ac.uk/pdbsum/3al2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3al2 ProSAT]</span></td></tr>
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-== Function ==
-[https://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>
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 == Publication Abstract from PubMed ==