Rho GTPase activating protein: Difference between revisions
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'''Rho GTPase activating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>,<ref>PMID:17222083</ref>. RhoGAPs contain a RhoGAP domain. | '''Rho GTPase activating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>,<ref>PMID:17222083</ref>. RhoGAPs contain a RhoGAP domain. | ||
*'''RhoGAP7''' activates the small GTPases RHOA, RHOB, RHOC and CDC42. | *'''RhoGAP7''' activates the small GTPases RHOA, RHOB, RHOC and CDC42. | ||
*'''RhoGAP9''' regulates adhesion of hematopoietic cells to the extracellular matrix. | |||
== Relevance == | == Relevance == | ||
Revision as of 10:13, 7 August 2024
FunctionRho GTPase activating protein (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions[1],[2]. RhoGAPs contain a RhoGAP domain.
RelevanceRhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy[3],[4] . Structural highlightsThe contains a and GDP[5]. Water molecules are shown as red spheres. . 3D structures of Rho GTPase activating proteinRho GTPase activating protein 3D structures
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ReferencesReferences
- ↑ Moon SY, Zheng Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 2003 Jan;13(1):13-22. PMID:12480336
- ↑ Tcherkezian J, Lamarche-Vane N. Current knowledge of the large RhoGAP family of proteins. Biol Cell. 2007 Feb;99(2):67-86. doi: 10.1042/BC20060086. PMID:17222083 doi:http://dx.doi.org/10.1042/BC20060086
- ↑ Kandpal RP. Rho GTPase activating proteins in cancer phenotypes. Curr Protein Pept Sci. 2006 Aug;7(4):355-65. PMID:16918449
- ↑ Song W, Chen J, Li S, Li D, Zhang Y, Zhou H, Yu W, He B, Zhang W, Li L. Rho GTPase Activating Protein 9 (ARHGAP9) in Human Cancers. Recent Pat Anticancer Drug Discov. 2022;17(1):55-65. PMID:34365932 doi:10.2174/1574892816666210806155754
- ↑ Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF. MgF(3)(-) as a transition state analog of phosphoryl transfer. Chem Biol. 2002 Mar;9(3):375-81. PMID:11927263