2wez: Difference between revisions

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 <StructureSection load='2wez' size='340' side='right'caption='[[2wez]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wez]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEZ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wez]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEZ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZYE:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-1-ETHYL-4-(2-OXOPYRROLIDIN-1-YL)-1H-INDOLE-6-CARBOXAMIDE'>ZYE</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tqf|1tqf]], [[1xn3|1xn3]], [[2vnm|2vnm]], [[1m4h|1m4h]], [[2fdp|2fdp]], [[1xn2|1xn2]], [[2viy|2viy]], [[2va6|2va6]], [[2vie|2vie]], [[2vj6|2vj6]], [[2viz|2viz]], [[2b8l|2b8l]], [[1ym4|1ym4]], [[1sgz|1sgz]], [[2va5|2va5]], [[2b8v|2b8v]], [[1ujk|1ujk]], [[1fkn|1fkn]], [[1xs7|1xs7]], [[2vij|2vij]], [[2va7|2va7]], [[1ym2|1ym2]], [[2vj9|2vj9]], [[2vkm|2vkm]], [[2vnn|2vnn]], [[1py1|1py1]], [[1w50|1w50]], [[1ujj|1ujj]], [[2vj7|2vj7]], [[1w51|1w51]], [[2wf3|2wf3]], [[2wf1|2wf1]], [[2wf4|2wf4]], [[2wf0|2wf0]], [[2wf2|2wf2]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZYE:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-1-ETHYL-4-(2-OXOPYRROLIDIN-1-YL)-1H-INDOLE-6-CARBOXAMIDE'>ZYE</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wez OCA], [https://pdbe.org/2wez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wez RCSB], [https://www.ebi.ac.uk/pdbsum/2wez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wez ProSAT]</span></td></tr>
 </table>
-== Function ==
-[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 16: / Line 13: @@
    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wez_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 37: / Line 34: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Memapsin 2]]
+[[Category: Charrier N]]
-[[Category: Brien, A O]]
+[[Category: Clarke B]]
-[[Category: Charrier, N]]
+[[Category: Cutler L]]
-[[Category: Clarke, B]]
+[[Category: Demont E]]
-[[Category: Cutler, L]]
+[[Category: Dingwall C]]
-[[Category: Demont, E]]
+[[Category: Dunsdon R]]
-[[Category: Dingwall, C]]
+[[Category: Hawkins J]]
-[[Category: Dunsdon, R]]
+[[Category: Howes C]]
-[[Category: Hawkins, J]]
+[[Category: Hubbard J]]
-[[Category: Howes, C]]
+[[Category: Hussain I]]
-[[Category: Hubbard, J]]
+[[Category: Maile G]]
-[[Category: Hussain, I]]
+[[Category: Matico R]]
-[[Category: Maile, G]]
+[[Category: Mosley J]]
-[[Category: Matico, R]]
+[[Category: Naylor A]]
-[[Category: Mosley, J]]
+[[Category: O'Brien A]]
-[[Category: Naylor, A]]
+[[Category: Redshaw S]]
-[[Category: Redshaw, S]]
+[[Category: Rowland P]]
-[[Category: Rowland, P]]
+[[Category: Smith KJ]]
-[[Category: Smith, K J]]
+[[Category: Soleil V]]
-[[Category: Soleil, V]]
+[[Category: Sweitzer S]]
-[[Category: Sweitzer, S]]
+[[Category: Theobald P]]
-[[Category: Theobald, P]]
+[[Category: Vesey D]]
-[[Category: Vesey, D]]
+[[Category: Walter DS]]
-[[Category: Walter, D S]]
+[[Category: Wayne G]]
-[[Category: Wayne, G]]
-[[Category: Alternative splicing]]
-[[Category: Asp-2]]
-[[Category: Aspartyl protease]]
-[[Category: Bace-1]]
-[[Category: Beta-secretase]]
-[[Category: Beta-site app cleaving enzyme]]
-[[Category: Disulfide bond]]
-[[Category: Glycoprotein]]
-[[Category: Hydrolase]]
-[[Category: Memapsin-2]]
-[[Category: Membrane]]
-[[Category: Polymorphism]]
-[[Category: Protease]]
-[[Category: Transmembrane]]
-[[Category: Zymogen]]