Contactin: Difference between revisions
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**[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human <br /> | **[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human <br /> | ||
**[[2ee2]] – hCNTN FN3 domains - NMR <br /> | **[[2ee2]] – hCNTN FN3 domains 798-903 - NMR <br /> | ||
**[[5e53]] – cCNTN FN1-FN3 domains – chicken <br /> | **[[7ol2]] – mCNTN Ig1-Ig6 domains 28-608 - mouse <br /> | ||
**[[5e53]] – cCNTN FN1-FN3 domains 601-893 – chicken <br /> | |||
* Contactin-2 | * Contactin-2 | ||
**[[2om5]] – hCNTN Ig1-Ig4 domains | **[[8k53]], [[9ba4]] – hCNTN – Cryo EM <br /> | ||
**[[5e7l]] – mCNTN FN1-FN3 domains – | **[[2om5]] – hCNTN Ig1-Ig4 domains 34-414 <br /> | ||
**[[8k3j]] – hCNTN Ig1-Ig6<br /> | |||
**[[9ba5]] – hCNTN Ig1-Ig6 – Cryo EM<br /> | |||
**[[5e7l]] – mCNTN FN1-FN3 domains 609-911 <br/ > | |||
**[[8a0y]] – mCNTN Ig1-Ig6 domains 28-608 <br /> | |||
**[[7ol4]] – mCNTN Ig1-Ig6 domains + neurofascin<br /> | |||
* Contactin-3 | * Contactin-3 | ||
Latest revision as of 13:45, 6 February 2025
FunctionContactin (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems[1].
DiseaseMutations in contactin-4, contactin-5 and contactin-6 confer risk of autism [4].
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3D structures of contactin3D structures of contactin
Updated on 06-February-2025
ReferencesReferences
- ↑ Rush AM, Craner MJ, Kageyama T, Dib-Hajj SD, Waxman SG, Ranscht B. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005 Jul;22(1):39-49. PMID:16029194 doi:http://dx.doi.org/10.1111/j.1460-9568.2005.04186.x
- ↑ Chatterjee M, Del Campo M, Morrema THJ, de Waal M, van der Flier WM, Hoozemans JJM, Teunissen CE. Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease. Alzheimers Res Ther. 2018 Jun 1;10(1):52. PMID:29859129 doi:10.1186/s13195-018-0383-x
- ↑ Mercati O, Danckaert A, André-Leroux G, Bellinzoni M, Gouder L, Watanabe K, Shimoda Y, Grailhe R, De Chaumont F, Bourgeron T, Cloëz-Tayarani I. Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites. Biol Open. 2013 Mar 15;2(3):324-34. PMID:23519440 doi:10.1242/bio.20133343
- ↑ Cottrell CE, Bir N, Varga E, Alvarez CE, Bouyain S, Zernzach R, Thrush DL, Evans J, Trimarchi M, Butter EM, Cunningham D, Gastier-Foster JM, McBride KL, Herman GE. Contactin 4 as an autism susceptibility locus. Autism Res. 2011 Jun;4(3):189-99. doi: 10.1002/aur.184. Epub 2011 Feb 9. PMID:21308999 doi:http://dx.doi.org/10.1002/aur.184