2jzm: Difference between revisions
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==Chymotrypsin inhibitor C1 from Nicotiana alata== | ==Chymotrypsin inhibitor C1 from Nicotiana alata== | ||
<StructureSection load='2jzm' size='340' side='right'caption='[[2jzm | <StructureSection load='2jzm' size='340' side='right'caption='[[2jzm]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZM FirstGlance]. <br> | <table><tr><td colspan='2'>[[2jzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZM FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzm OCA], [https://pdbe.org/2jzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzm RCSB], [https://www.ebi.ac.uk/pdbsum/2jzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzm ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jzm OCA], [https://pdbe.org/2jzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jzm RCSB], [https://www.ebi.ac.uk/pdbsum/2jzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jzm ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q40378_NICAL Q40378_NICAL] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/2jzm_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/2jzm_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Nicotiana alata]] | [[Category: Nicotiana alata]] | ||
[[Category: Anderson | [[Category: Anderson MA]] | ||
[[Category: Craik | [[Category: Craik DJ]] | ||
[[Category: Schirra | [[Category: Schirra HJ]] | ||
Latest revision as of 04:07, 21 November 2024
Chymotrypsin inhibitor C1 from Nicotiana alataChymotrypsin inhibitor C1 from Nicotiana alata
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedOrnamental tobacco (Nicotiana alata) produces a series of 6 kDa proteinase inhibitors belonging to the potato type II inhibitor family. These proteins inhibit trypsin and chymotrypsin, the main digestive enzymes of predatory insects, thus leading to starvation, impaired larval development or death. In this context, the three-dimensional structures of these inhibitors are important for developing novel strategies for pest control. The solution structures of C1 and T1, the two main prototypes of the N. alata inhibitors, were originally determined more than a decade ago (J. Mol. Biol. 242, 231-243 (1994) and Biochemistry 34, 14304-14311 (1995)). Since then methods for NMR structure calculations have evolved considerably. Here we report the refinement of the structures of C1 and T1 with state-of-the-art protocols for NMR structure calculations. This refinement leads to an improved quality of the structures, making them a more reliable basis for the development of novel pesticides and modeling applications. Structural refinement of insecticidal plant proteinase inhibitors from Nicotiana alata.,Schirra HJ, Anderson MA, Craik DJ Protein Pept Lett. 2008;15(9):903-9. PMID:18991765[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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