2g3v: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2g3v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G3V FirstGlance]. <br> | <table><tr><td colspan='2'>[[2g3v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G3V FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3v OCA], [https://pdbe.org/2g3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g3v RCSB], [https://www.ebi.ac.uk/pdbsum/2g3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3v ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3v OCA], [https://pdbe.org/2g3v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g3v RCSB], [https://www.ebi.ac.uk/pdbsum/2g3v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CAGS_HELPY CAGS_HELPY] | [https://www.uniprot.org/uniprot/CAGS_HELPY CAGS_HELPY] | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
CagZ, a 23 kDa protein encoded by the cagZ gene (HP0526) of the cag pathogenicity island of Helicobacter pylori, has been cloned, over-expressed, purified and its three-dimensional structure determined. The protein consists of a single compact L-shaped domain, composed of seven alpha-helices including about 70% of the total residues. Three-dimensional homology searches did not reveal structural homologues, and CagZ can be considered representative of a new protein fold. The presence of a disordered C-terminal tail and the nature of the molecular surface suggest that CagZ may participate in the interaction of effector proteins with one or more components of the H.pylori type IV secretion system on the cytoplasmic side of the inner membrane. | |||
Crystal structure of CagZ, a protein from the Helicobacter pylori pathogenicity island that encodes for a type IV secretion system.,Cendron L, Seydel A, Angelini A, Battistutta R, Zanotti G J Mol Biol. 2004 Jul 16;340(4):881-9. PMID:015223328<ref>PMID:015223328</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2g3v" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Latest revision as of 10:54, 23 October 2024
Crystal structure of CagS (HP0534, Cag13) from Helicobacter pyloriCrystal structure of CagS (HP0534, Cag13) from Helicobacter pylori
Structural highlights
FunctionPublication Abstract from PubMedCagZ, a 23 kDa protein encoded by the cagZ gene (HP0526) of the cag pathogenicity island of Helicobacter pylori, has been cloned, over-expressed, purified and its three-dimensional structure determined. The protein consists of a single compact L-shaped domain, composed of seven alpha-helices including about 70% of the total residues. Three-dimensional homology searches did not reveal structural homologues, and CagZ can be considered representative of a new protein fold. The presence of a disordered C-terminal tail and the nature of the molecular surface suggest that CagZ may participate in the interaction of effector proteins with one or more components of the H.pylori type IV secretion system on the cytoplasmic side of the inner membrane. Crystal structure of CagZ, a protein from the Helicobacter pylori pathogenicity island that encodes for a type IV secretion system.,Cendron L, Seydel A, Angelini A, Battistutta R, Zanotti G J Mol Biol. 2004 Jul 16;340(4):881-9. PMID:015223328[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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