1w8d: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w8d OCA], [https://pdbe.org/1w8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w8d RCSB], [https://www.ebi.ac.uk/pdbsum/1w8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w8d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w8d OCA], [https://pdbe.org/1w8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w8d RCSB], [https://www.ebi.ac.uk/pdbsum/1w8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w8d ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DECR_HUMAN DECR_HUMAN] The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS.<ref>PMID:24847004</ref>
== Function ==
[https://www.uniprot.org/uniprot/DECR_HUMAN DECR_HUMAN] Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.<ref>PMID:15531764</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/1w8d_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/1w8d_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>

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