2w2r: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2w2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vesicular_stomatitis_virus Vesicular stomatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2R FirstGlance]. <br> | <table><tr><td colspan='2'>[[2w2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vesicular_stomatitis_virus Vesicular stomatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2R FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2r OCA], [https://pdbe.org/2w2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2r RCSB], [https://www.ebi.ac.uk/pdbsum/2w2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2r ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2r OCA], [https://pdbe.org/2w2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2r RCSB], [https://www.ebi.ac.uk/pdbsum/2w2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MATRX_VSNJO MATRX_VSNJO] Plays a major role in assembly and budding of virion. Condensates the ribonucleocapsid core during virus assembly. Shut off cellular transcription by inhibiting mRNA nuclear export through direct interaction with host RAE1-NUP98 complex. This shutoff presumably inhibits interferon signaling and thus establishment of antiviral state in virus infected cells. Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 13: | Line 15: | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2r_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2r_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| Line 33: | Line 35: | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Vesicular stomatitis virus]] | [[Category: Vesicular stomatitis virus]] | ||
[[Category: Assenberg | [[Category: Assenberg R]] | ||
[[Category: Bourhy | [[Category: Bourhy H]] | ||
[[Category: Delmas | [[Category: Delmas O]] | ||
[[Category: Gholami | [[Category: Gholami A]] | ||
[[Category: Graham | [[Category: Graham SC]] | ||
[[Category: Grimes | [[Category: Grimes JM]] | ||
[[Category: Owens | [[Category: Owens RJ]] | ||
[[Category: Stuart | [[Category: Stuart DI]] | ||
[[Category: Talbi | [[Category: Talbi C]] | ||
[[Category: Verma | [[Category: Verma A]] | ||