7hi9: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 7hi9 is ON HOLD
+==PanDDA analysis group deposition of ground-state model of human Brachyury G177D variant==
+<StructureSection load='7hi9' size='340' side='right'caption='[[7hi9]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
-Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7hi9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7HI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7HI9 FirstGlance]. <br>
-Description: PanDDA analysis group deposition of ground-state model of human Brachyury G177D variant
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Sherestha, L]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7hi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7hi9 OCA], [https://pdbe.org/7hi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7hi9 RCSB], [https://www.ebi.ac.uk/pdbsum/7hi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7hi9 ProSAT]</span></td></tr>
-[[Category: Bountra, C]]
+</table>
-[[Category: Gileadi, O]]
+== Disease ==
-[[Category: Gavard, A.E]]
+[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication.  The disease is caused by mutations affecting the gene represented in this entry.
-[[Category: Arrowsmith, C.H]]
+== Function ==
-[[Category: Edwards, A]]
+[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]
-[[Category: Burgess-Brown, N.A]]
+__TOC__
-[[Category: Newman, J.A]]
+</StructureSection>
-[[Category: Von Delft, F]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arrowsmith CH]]
+[[Category: Bountra C]]
+[[Category: Burgess-Brown NA]]
+[[Category: Edwards A]]
+[[Category: Gavard AE]]
+[[Category: Gileadi O]]
+[[Category: Newman JA]]
+[[Category: Sherestha L]]
+[[Category: Von Delft F]]