Bone morphogenetic protein: Difference between revisions

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== Function ==
== Function ==
   
   
'''Bone morphogenetic protein''' (BMP) are growth factors which can induce formation of bone and cartllage'<ref>PMID:19900831</ref>.  Over 20 BMPs are known at present.  BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins. For details on '''BMP-7''' see [[Student Projects for UMass Chemistry 423 Spring 2012-4]]. See also  
'''Bone morphogenetic protein''' (BMP) are growth factors which can induce formation of bone and cartllage'<ref>PMID:19900831</ref>.  Over 20 BMPs are known at present.  BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins.  
*BMP-1 cleaves the C-propeptides of type I pro collagen during the synthesis of extracellular collagen fibrils<ref>PMID:12637537</ref>.
For details on '''BMP-7''' see [[Student Projects for UMass Chemistry 423 Spring 2012-4]]. See also  
*[[Growth factors]],  
*[[Growth factors]],  
*[[Enzyme-linked receptor]]  
*[[Enzyme-linked receptor]]  

Revision as of 12:43, 30 May 2024

Function

Bone morphogenetic protein (BMP) are growth factors which can induce formation of bone and cartllage'[1]. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins.

  • BMP-1 cleaves the C-propeptides of type I pro collagen during the synthesis of extracellular collagen fibrils[2].

For details on BMP-7 see Student Projects for UMass Chemistry 423 Spring 2012-4. See also

Relevance

Recombinant BMP is used in oral surgery and spinal fusion.

Disease

BMP-7 is involved in chronic kidney disease[3].

3D structures of bone morphogenetic protein

Bone morphogenetic protein 3D structures


Human BMP-2 (grey and green) complex with BMP receptor extracellular domain (yellow and pink) (PDB entry 2qja)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Reddi AH, Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. doi:, 10.1016/j.cytogfr.2009.10.015. Epub 2009 Nov 8. PMID:19900831 doi:http://dx.doi.org/10.1016/j.cytogfr.2009.10.015
  2. ↑ Hartigan N, Garrigue-Antar L, Kadler KE. Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity. J Biol Chem. 2003 May 16;278(20):18045-9. PMID:12637537 doi:10.1074/jbc.M211448200
  3. ↑ Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci. 2008 May 1;13:4726-39. PMID:18508541

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