1sjh: Difference between revisions
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'''HLA-DR1 complexed with a 13 residue HIV capsid peptide''' | '''HLA-DR1 complexed with a 13 residue HIV capsid peptide''' | ||
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[[Category: Walker, B D.]] | [[Category: Walker, B D.]] | ||
[[Category: Zavala-Ruiz, Z.]] | [[Category: Zavala-Ruiz, Z.]] | ||
[[Category: | [[Category: Antigen]] | ||
[[Category: | [[Category: Capsid]] | ||
[[Category: | [[Category: Gag]] | ||
[[Category: | [[Category: Hiv-1]] | ||
[[Category: | [[Category: Hla-dr1]] | ||
[[Category: | [[Category: Major histocompatibility protein complex]] | ||
[[Category: | [[Category: Mhc class ii]] | ||
[[Category: | [[Category: Peptide]] | ||
[[Category: | [[Category: Superantigen]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:46:48 2008'' | |||
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Revision as of 08:46, 3 May 2008
HLA-DR1 complexed with a 13 residue HIV capsid peptide
OverviewOverview
T cells generally recognize peptide antigens bound to MHC proteins through contacts with residues found within or immediately flanking the seven- to nine-residue sequence accommodated in the MHC peptide-binding groove. However, some T cells require peptide residues outside this region for activation, the structural basis for which is unknown. Here, we have investigated a HIV Gag-specific T cell clone that requires an unusually long peptide antigen for activation. The crystal structure of a minimally antigenic 16-mer bound to HLA-DR1 shows that the peptide C-terminal region bends sharply into a hairpin turn as it exits the binding site, orienting peptide residues outside the MHC-binding region in position to interact with a T cell receptor. Peptide truncation and substitution studies show that both the hairpin turn and the extreme C-terminal residues are required for T cell activation. These results demonstrate a previously unrecognized mode of MHC-peptide-T cell receptor interaction.
About this StructureAbout this Structure
1SJH is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.
ReferenceReference
A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition., Zavala-Ruiz Z, Strug I, Walker BD, Norris PJ, Stern LJ, Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13279-84. Epub 2004 Aug 26. PMID:15331779 Page seeded by OCA on Sat May 3 08:46:48 2008