2yro: Difference between revisions

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==Solution structure of the C-terminal Gal-bind lectin protein from Human Galectin-8==
==Solution structure of the C-terminal Gal-bind lectin protein from Human Galectin-8==
<StructureSection load='2yro' size='340' side='right'caption='[[2yro]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2yro' size='340' side='right'caption='[[2yro]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRO FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LGALS8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yro OCA], [https://pdbe.org/2yro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yro RCSB], [https://www.ebi.ac.uk/pdbsum/2yro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yro ProSAT], [https://www.topsan.org/Proteins/RSGI/2yro TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yro OCA], [https://pdbe.org/2yro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yro RCSB], [https://www.ebi.ac.uk/pdbsum/2yro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yro ProSAT], [https://www.topsan.org/Proteins/RSGI/2yro TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>
[https://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Koshiba, S]]
[[Category: Koshiba S]]
[[Category: Structural genomic]]
[[Category: Tomizawa T]]
[[Category: Tomizawa, T]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Gal-bind lectin]]
[[Category: Galectin]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Sugar binding]]
[[Category: Sugar binding protein]]

Latest revision as of 22:16, 29 May 2024

Solution structure of the C-terminal Gal-bind lectin protein from Human Galectin-8Solution structure of the C-terminal Gal-bind lectin protein from Human Galectin-8

Structural highlights

2yro is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

LEG8_HUMAN Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Ideo H, Matsuzaka T, Nonaka T, Seko A, Yamashita K. Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. J Biol Chem. 2011 Apr 1;286(13):11346-55. Epub 2011 Feb 2. PMID:21288902 doi:10.1074/jbc.M110.195925
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