2gow: Difference between revisions
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==Solution structure of BC059385 from Homo sapiens== | ==Solution structure of BC059385 from Homo sapiens== | ||
<StructureSection load='2gow' size='340' side='right'caption='[[2gow | <StructureSection load='2gow' size='340' side='right'caption='[[2gow]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2gow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOW FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gow OCA], [https://pdbe.org/2gow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gow RCSB], [https://www.ebi.ac.uk/pdbsum/2gow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gow ProSAT], [https://www.topsan.org/Proteins/CESG/2gow TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gow OCA], [https://pdbe.org/2gow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gow RCSB], [https://www.ebi.ac.uk/pdbsum/2gow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gow ProSAT], [https://www.topsan.org/Proteins/CESG/2gow TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/UBL3_HUMAN UBL3_HUMAN] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lytle BL]] | |||
[[Category: Peterson FC]] | |||
[[Category: Lytle | [[Category: Volkman BF]] | ||
[[Category: Peterson | [[Category: De la Cruz NB]] | ||
[[Category: Volkman | |||
[[Category: | |||
Latest revision as of 21:59, 29 May 2024
Solution structure of BC059385 from Homo sapiensSolution structure of BC059385 from Homo sapiens
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe protein Bc059385, whose solution structure is reported here, is the human representative of a recently identified family of membrane-anchored ubiquitin-fold (MUB) proteins. Analysis of their similarity to ubiquitin indicates that homologous amino acid residues in MUBs form a hydrophobic surface very similar to the recognition patch surrounding Ile-44 in ubiquitin. This suggests that MUBs may interact with proteins containing an alpha-helical motif similar to those of some ubiquitin binding domains. A disordered loop common to MUBs may also provide a second protein interaction site. From the available data, it is probable that this protein is prenylated and associated with the membrane. With <20% identity to ubiquitin, the MUB family further expands the sequence space that maps to the beta-grasp fold, and adds membrane localization to its list of functional roles. Solution structure of a membrane-anchored ubiquitin-fold (MUB) protein from Homo sapiens.,de la Cruz NB, Peterson FC, Lytle BL, Volkman BF Protein Sci. 2007 Jul;16(7):1479-84. Epub 2007 Jun 13. PMID:17567738[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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